儿童川崎病合并肺炎支原体感染的耐药性及抗菌药物治疗分析

Drug resistance analysis and antibiotic therapy of children with Kawasaki disease complicated with pneumonia mycoplasma infection

目的观察分析川崎病住院患儿合并肺炎支原体感染的耐药性分析及抗菌药物治疗效果,为临床治疗用药提供参考依据。方法选取川崎病住院患儿共120例。根据患儿是否有合并肺炎支原体感染分为感染组和非感染组。统计两组患儿实验室检查指标。川崎病合并肺炎支原体感染患儿的耐药性分析以及抗菌药物的治疗效果。结果川崎病合并肺炎支原体感染的并发感染率为26.7%,比较感染组和非感染组的实验室检查结果,其中包括白细胞计数,红细胞沉降率,超敏C反应蛋白,血红蛋白、血小板计数以及发热的天数,两组实验室检查结果比较没有统计学意义。阿奇霉素的敏感性最高有97.37%,其次是利福霉素有89.47%。耐药性最高的是克拉霉素和罗红霉素,分别是23.68%和21.05%,其次是克林霉素18.42%。采用大环内酯类抗菌药物治疗的总有效率为90.00%。结论川崎病合并肺炎支原体感染采用阿奇霉素、利福霉素大环内酯类抗菌药物治疗的治疗效果较好,耐药性较低。

Objective To analyze the drug resistance and antibiotic therapy of children with Kawasaki dis-ease complicated with pneumonia mycoplasma infection. Methods From March 2008 to March 2013, 120 children with Kawasaki disease were selected and then divided into two groups according to whether they were infected with Mycoplasma pneumonia. The drug resistance of Mycoplasma pneumonia infection complicated with Kawasaki disease were analyzed. Results The infection rate of Kawasaki disease complicated with pneumonia mycoplasma was 26. 7%. There was no significant difference in white blood cell count, erythrocyte sedimentation rate, high-sensitivity C-reactive protein, hemoglobin, platelet count, and fever between the two groups. Azithromycin had the highest sensi-tivity of 97. 37%, followed by rifamycin （89. 47%）. The highest resistance to clarithromycin and roxithromycin was respectively 23. 68% and 21. 05%, followed by clindamycin （18. 42%）. The total effective rate of Macrolide antibi-otic therapy was 90. 00%. Conclusion The clinical effect of azithromycin and Miso macrolide antibiotic therapy is better with lower resistance.