老年肺炎支原体肺炎患者IL-10、TNF-α、TGF-β1的变化及其临床意义分析

Changes and its clinical significance of IL-10,TNF-α and TGF-β1 in senile patients with pneumonia mycoplasma infection

目的探讨老年肺炎支原体肺炎患者血清白介素10(IL-10)、肿瘤坏死因子(TNF-α)、转化生长因子(TGF-β1)的变化及其临床意义。方法收集2010年10月至2013年10月入住我院的55例老年肺炎支原体肺炎患者(MPP)的临床资料,另外选择同期于我院进行体检的健康者25名患者的体检资料作为对照组。两组患者均采用了酶联免疫吸附法(ELISA法)对其血清IL-10、TNF-α及TGF-β1水平进行了分析,比较急性期及恢复期与对照组上述指标水平、重症组与轻症组急性期及恢复期上述指标水平。结果 1肺炎支原体肺炎患者急性期及恢复期血清上述指标水平均显著高于对照组(P<0.05),且急性期患者血清TNF-α及TGF-β1水平均显著高于恢复期(P<0.05),但急性期与恢复期血清IL-10水平差异无统计学意义(P>0.05);2重症组急性期患者血清IL-10、TNF-α及TGF-β1水平均显著高于轻症组(P<0.05);3重症组恢复期患者血清IL-10、TNF-α及TGF-β1水平均显著高于轻症组(P<0.05)。结论老年肺炎支原体感染患者血清IL-10、TNF-α、TGF-β1水平高低反映了患者疾病严重程度及病情缓解情况,具有十分重要的临床意义与价值。

Objective To investigate the changes and its clinical significance of serum interleukin 10 （ IL-10）, tumor necrosis factor alpha （TNF-α）, transforming growth factor （TGF-β1） in senile patients with pneumonia mycoplasma infection. Methods 55 elderly patients with Mycoplasma pneumoniae pneumonia were collected as the study group, and 25 healthy people during the same period were selected as the control group. The levels of IL-10, TNF-α and TGF-β1 in the two groups were analyzed by ELISA method. The levels were compared among different stages of those patients. Results ①The indexes during the acute and recovery phase were both higher than those of the control group （P〈0. 05）, and the serum levels of TNF-αand TGF-β1 during the acute phase were significantly higher than those during the recovery phase （P〈0. 05）, but there was no statistical significance in IL-10 between the acute and recovery phase （P〉0. 05）. ② The levels of IL-10, TNF-α and TGF-β1 were higher in the severe group than in the mild group during the acute phase （P〈0. 05）. ③The levels of IL-10, TNF-αand TGF-β1 were higher in the severe group than in the mild group during the recovery phase （P〈0. 05）. Conclusion The levels of IL-10, TNF-α and TGF-β1 in elder patients with pneumonia mycoplasma infection can reflect the severity of illness and dis-ease remission with a great clinical significance.