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OSAHS与胰岛素抵抗的相关性研究 被引量：2

Research of correlation between obstructive sleep apnea hypopnea syndrome and insulin resistance
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摘要 目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与胰岛素抵抗的相关性。方法分析我院就诊的70名OSAHS患者的临床资料,选取健康体检者作为对照,比较两组受试者多导睡眠监测(PSG)与胰岛素相关指标,并分析OSAHS与胰岛素抵抗的相关性。结果观察组体质指数(BMI)高于对照组(P<0.05)。观察组FPG、FINS和HOMA-IR均显著高于对照组(P<0.01)。轻度(5≤AHI≤15)与中重度(AHI>15)两组最低血氧饱和度及平均血氧饱和度、FPG、FINS和HOMA-IR有统计学差异(P<0.05)。观察组HOMA-IR与AHI具有显著正相关,而与最低血氧饱和度和平均血氧饱和度分别呈负相关(P<0.05)。结论OSAHS与胰岛素抵抗的发生具有密切关系, Objective To analyze the correlation between obstructive sleep apnea hypopnea syndrome and insulin resistance. Methods The clinical data of 70 patients with obstructive sleep apnea hypopnea syndrome and 60 healthy people was analyzed. PSG and indexes of insulin were compared between the two groups, and the correlation between PSG and HOMA-IR was analyzed. Results BMI was higher in the observation group than in the control group （P〈0. 05）. The levels of FPG, FINS and HOMA-IR were significantly higher in the observation group than in the control group. The lowest oxygen saturation and average oxygen saturation, FPG, FINS and HOMA-IR showed significant difference between the mild group and the moderate/severe group. In the observation group, HOMA-IR was positively correlated with AHI, and negatively correlated with the lowest average oxygen saturation and oxygen saturation （P〈0. 05）. Conclusion OSAHS is closely related with insulin resistance.
作者 雷怀定 刘玉全 尤辉
机构地区 湖北医药学院附属太和医院
出处 《临床肺科杂志》 2015年第7期1312-1314,1322,共4页 Journal of Clinical Pulmonary Medicine
关键词 睡眠呼吸暂停 胰岛素抵抗 体质指数 血氧饱和度 多导睡眠监测 sleep apnea insulin resistance body mass index oxygen saturation polysomnography
分类号 R766 [医药卫生—耳鼻咽喉科]
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参考文献12

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二级参考文献15

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临床肺科杂志
2015年 第7期

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