中国肾移植术后并发恶性肿瘤趋势分析

Trend analysis of malignant tumor after renal transplantation in China

目的通过收集分析近10余年来我国公开报道的肾移植术后并发恶性肿瘤的流行病学及临床特征资料,试图揭示中国肾移植术后并发恶性肿瘤的变化趋势。方法以"肾移植"和"肿瘤"为检索词,检索中国学术期刊网络版总库和中国学术期刊数据库。严格筛选出符合标准的研究,分析恶性肿瘤总体情况、发生部位和地域差异等。结果共筛选出2003年至2014年9篇文献及首都医科大学附属北京友谊医院单中心肾移植病例共计15 120例,肾移植术后发生恶性肿瘤共计446例,肿瘤发生率为2.95%(446/15 120),移植后肿瘤以泌尿系统肿瘤(55.8%)为主。结论我国肾移植患者罹患恶性肿瘤的总发生率为2.95%,以泌尿系肿瘤最常见。因此,肾移植术后肿瘤筛查应作为患者随访的常规检查项目。

Objective To reveal the change trend of malignant tumor after renal transplantation in China based on the epidemiological and clinical features that were publicly reported in China in recent 10 years. Methods The search terms ‘renal transplantation’and ‘tumor’were searched on China Academic Journal Network Publishing Database and China Science Periodical Database to screen out the qualified researches strictly.General conditions,tumor sites and regional differences of malignant tumors were analyzed.Results Fifteen thousand one hundred and twenty cases from nine literatures published from 2003 to 2014 and a single-center experience of renal transplantation in Beijing Friendship Hospital of Capital Medical University were screened out.Four hundred and fourty-six cases had malignant tumor after renal transplantation with the total tumor incidence of 2.95% （446 /15 120） and the tumors were mainly urinary system tumors after transplantation （55.8%）.Conclusions The total incidence of malignant tumor in renal transplant recipients is 2.95% and the urinary system tumors are most common.Thus,tumor screening after renal transplantation should be taken as the routine examination during follow-up.