无症状性传播疾病对女性免疫不孕的影响分析

Impact asymptomatic aexually transmitted disease on female immune infertility

目的 为进一步探讨无症状性传播疾病对女性免疫不孕的影响.方法 从2010年1月开始对766例不孕女性患者和332例已正常生育妇女生殖道分泌物样本常规进行淋球菌和支原体培养、衣原体、涂片找结核杆菌、假丝酵母菌、滴虫等病原体以及用金标法定性检测抗精子抗体、抗卵巢抗体、抗子宫内膜抗体、抗心磷脂抗体及抗绒毛膜促性腺激素抗体检查.结果 无症状性传播疾病病原体以解脲支原体、衣原体和淋球菌为主,阳性率分别为33.68％、18.80％、14.62％,高于对照组的15.66％、12.65％、9.64％,差异有统计学意义（P＜0.05,P＜0.01）;无症状性性传播疾病病原体感染组的血液样本检测抗精子抗体、抗卵巢抗体、抗子宫内膜抗体、抗心磷脂抗体及抗绒毛膜促性腺激素抗体的阳性率为高于非感染组的,差异有统计学意义（P＜0.05,P＜0.01）;继发不孕患者中检测出上述五种抗体阳性比率高于原发不孕患者.结论 性传播疾病主要病原体为以UU、CT、NG为主,病原体引起女性泌尿生殖道感染后容易诱发机体产生抗精子抗体、抗卵巢抗体、抗子宫内膜抗体、抗心磷脂抗体;分娩、妇科手术可增加性传播性疾病发生的危险性,也是诱发女性免疫性不孕症的重要因素.

Objective To investigate the impact of asymptomatic sexually transmitted diseases on female immune infertility.Methods From January,2010,766 infertile women and 332 normal fertile women were retrospectively analyzed.Their secretion samples from the genital tracts were cultured to detect neisseria gonorrhoeae,chlamydia,mycoplasma routine,and smear to detect mycobacterium tuberculosis,candida,trichomonas,and other pathogens.Colloidal gold was used to detect serum anti-sperm antibody,anti-ovary antibody,anti-endometrial antibody,anti-cardiolipin antibody,and anti-human chorionic gonadotropin.The results were statistically analyzed.Results The main pathogens of asymptomatic sexually transmitted disease were neisseria gonorrhoeae,chlamydia trachomatis,and ureaplasma urealyticum,whose positive rates were 33.68% and 14.62%,which were higher than the control group＇s （15.66%,12.65%,9.64%）,with statistical differences （P 〈 0.05,P 〈 0.01）.The positive rates of anti-sperm antibody,anti-ovary antibody,anti-endometrial antibody,anti-cardiolipin antibody,and anti-hCG antibody were higher in the asymptomatic infection pathogens of sexually transmitted disease group than in the non-infection group,with statistical differences （P 〈 0.05,P 〈 0.01）,and were higher in the patients with secondary than primary infertility.Conclusions The main pathogens sexually transmitted diseases are UU,CT,and NG.The production of anti-sperm antibody,anti-ovary antibody,anti-endometrial antibody,and anti-cardiolipin antibody is easily induced the infection of female urogenital tract.Delivering and gynecological operation can increase the incidence of sexually transmitted diseases and increase the risk of immune antibody production and are factors causing female immune infertility.