山栀茶化学成分的研究

Research On the Chemical Constituents of Pittosporum glabratum

目的:对山栀茶的化学成分进行研究。方法:应用正、反相硅胶和Sephadex LH-20等柱层析方法分离纯化山栀茶,根据化合物的理化性质和波谱数据进行结构鉴定。结果:从山栀茶中分离得到7个化合物,分别鉴定为(1)丁香脂素-4,4'-双-O-β-D-葡萄糖苷、(2)紫丁香苷、(3)3,4,5-三甲氧基苯-1-O-β-D-呋喃芹糖-(1→6)-β-D-吡喃葡萄糖苷、(4)丁香脂素-4-O-β-D-吡喃葡萄糖苷、(5)异落叶松树脂醇-9'-O-β-D-吡喃葡萄糖苷、(6)南烛木树脂酚-9'-O-β-D-吡喃葡萄糖苷、(7)芥子醛葡萄糖苷。结论:化合物(2),(4),(5),(7)为首次从该植物中分离得到,为山栀茶质量控制指标性成分的选择提供了依据。

Objective： To study the chemical constituents of the root of Pittosporum glabratum.Methods： Various column chromatographic techniques including silica gel column chromatography（ CC）,reversed phase C18 CC and Sephadex LH-20 CC were used to isolate the constituents of P.Glabratum,whose structures were determined by physicochemical property and spectroscopic analysis.Results： Seven compounds were isolated from P. glabratum and their structures were identified as（ 1）syringaresinol-4,4 ＇-bis-O-β-D-glucopyranoside,（ 2） syringin,（ 3） 3,4,5-trimethoxyphenol-1-O-β-Dapiofuranosyl-（ 1→6）-β-D-glucopyranoside,（ 4） syringaresinol-4-O-β-D-glucopyranoside,（ 5） isolariciresinol 9＇-O-β-D-glucopyranoside,（ 6） lyoniresinol 9＇-O-β-D-glucopyranoside and（ 7） sinapaldehyde glucoside. Conclusions： Compounds（ 2）,（ 4）,（ 5）,and（ 7） are isolated from P. glabratum for the first time and can be regarded as the chemical markers for P. Glabratumt＇s quality control.