影响2型糖尿病患者血清CA19-9水平的相关因素

Related Factors Affecting Serum CA19-9 Level in Patients with Type 2 Diabetes Mellitus

目的:探讨影响2型糖尿病(T2DM)患者血清CA19-9的相关因素。方法:以256例住院T2DM患者为研究对象,按血清CA19-9水平分为阴性组(<39 U/m L)和阳性组(≥39 U/m L),比较两组空腹血糖(FBS)、糖化血红蛋白(Hb A1c)、血脂、超敏C反应蛋白(hs-CRP)水平,计算FBS、Hb A1c、血脂、hs-CRP等指标与CA19-9的相关性;以年龄、性别、体重、Hb A1c、FBS、血脂及hs-CRP等为自变量,进行多元回归分析,比较各变量对CA19-9的影响程度。结果:CA19-9阳性组血清FBS、Hb A1c、hs-CRP水平明显高于阴性组,差异有统计学意义(P<0.05);CA19-9与FBS、Hb A1c、甘油三酯(TG)及hs-CRP存在线性关系,Hb A1c是影响CA19-9的主要因素。结论:T2DM患者CA19-9水平与FBS、Hb A1c和hs-CRP有关。

Objective： To investigate related factors affecting serumLevels of CA19-9 in patients with type 2 diabetes mellitus. Methods： A total of 256 hospitalized patients with type 2 diabetes mellitus were divided into two groups according to the serumLevels of CA19-9,negative group（ 39 U / mL）and positive group（ ≥39 U / mL）. Concentrations of fasting blood glucose（ FBS）,glycosylated hemoglonin（ HbA1c）,blood lipids,high sensitive C reactive protein（ hs-CRP） were compared between two groups. Correlations of FBS,Hb A1 c,blood lipids and hs-CRP with serum CA19-9 levels were calculated. Multiple regression analysis was also performed with age,sex,disease course,blood lipid,hs-CRP as the independent variables to compare influences of these variables on the serum CA19-9 level. Results： Serum FBS,Hb A1 c,and hs-CRP levels were significantly higher in the CA19-9 positive group than those of negative group. The difference was statistically significant（ P〈0. 05）. There is a linear relationship between the serum CA19-9 level and concentrations of FBS,Hb A1 c,triglyceride（ TG） and hs-CRP. Conclusions： FBS,Hb A1 c and hs-CRP have influences on the serum CA19-9level in patients with type 2 diabetes mellitus.