血清降钙素原及C反应蛋白在肿瘤并发感染时的诊断价值

Clinical Diagnostic Value of Serum Procalcitonin and C-Reactive Protein in Tumor Complicated with Infection

目的:探讨血清降钙素原(PCT)及C反应蛋白(CRP)在诊断肿瘤并发感染中的价值。方法:93例肿瘤患者,分为肿瘤放化疗后并发感染组(A组)、肿瘤未放化疗并发感染组(B组)和肿瘤非感染组(对照组);抽取3组患者静脉血采用发光免疫分析法检测血清PCT水平,免疫比浊法检测CRP含量,比较3组患者血清PCT、CRP水平、阳性率,分析PCT、CRP诊断肿瘤并发感染的灵敏度、特异度。结果:A、B组与对照组比较,血清PCT、CRP含量均明显升高(P<0.05);A、B组血清PCT阳性率分别为84.85%、88.46%,对照组为11.76%,A、B组高于对照组(P<0.05);A、B组CRP阳性率分别为96.97%、96.15%,对照组为85.29%,A、B组高于对照组(P>0.05);血清PCT、CRP诊断肿瘤并发感染的特异度分别为88.24%、14.71%,PCT的特异度高于CRP。结论:PCT水平增高可作为诊断肿瘤患者并发感染的敏感和特异指标。

Objective： To investigate the clinical diagnostic value of serum procalcitonin（ PCT） and C-reactive protein（ CRP） in cancer patients complicated with infection. Methods： A total of 93 cases of cancer were divided into the group of tumor complicated with infection after chemoradiotherapy（ group A,n = 33）,the group of tumor complicated with infection without chemoradiotherapy（ group B,n = 26）,and the group of tumor with no infection（ control group,n = 34）. The venous blood was drawn for detection of serum PCT level by chemiluminescent immunoassay and detection of CRP level by immunoturbidimetry. The PCT level,CRP level and positive rates were compared between 3groups,and sensitivity and specificity in diagnosing tumor complicated with infection were analyzed.Results： The serum PCT and CRP levels in groups A and B were significantly increased compared with control group（ P〈0. 05）. The positive rate of serum PCT was 84. 85% in group A and 88. 46% in group B,which were significantly higher than that in control group（ P〈0. 05）. The positive rate of CRP was 96. 97% in group A and 96. 15% in group B,which were not significantly higher than that in control group（ P〉0. 05）. The specificity of serum PCT and CRP in diagnosing tumor complicated with infection was 88. 24% and 14. 71%,respectively. Conclusion： Serum PCT is an effective indicator to diagnose tumor complicated with infection. The specificity of PCT is significantly better than that of CRP