二联和三联血清标志物在胎儿唐氏综合征筛查中的应用比较

Sensitivity Study double,triple serum markers for screening for fetal Down syndrome

目的探讨二联和三联血清标志物在胎儿唐氏综合征(DS)筛查中的应用比较。方法采用时间分辨荧光免疫分析仪检测3280例孕妇血清u E3、AFP、fβ-h CG,以1/270作为风险切割值,比较二联、三联筛查方法的阳性率、检出率、假阳性率。结果 3282例孕妇中,共筛查出6例DS胎儿(0.18%);三联筛查检出率(83.33%)、风险值明显高于二联筛查,二联与三联筛查阳性率、假阳性率比较差异无统计学意义。结论孕中期血清三联筛查DS敏感性明显高于二联筛查,建议在DS筛查中推广及应用。

Objective： To investigate sensitivity of double, triple serum markers for screening for fetal Down syndrome （DS） . Methods： 3280 cases of pregnant women serum uE3, AFP, f beta hCG were detected by time-resolved fluorescence immunoassay and analyzed, 1/270 as risk cutting value, positive rate, detection rate and false positive rate were compared between double triple. Results： 3282 cases of pregnant women were screened out of six cases of DS fetuses （0.18%） ; triple screening detection rate （83.33%） , risk value were significantly higher than duplex screening, there were no statistically significant of positive rate, false positive rate between two methods. Conclusion： Mid pregnancy serum triple screening DS sensitivity is significantly higher than duplex screening, Suggestions promoted and applied in DS screening.