组织血型抗原:轮状病毒可能的潜在受体

Histo-Blood Group Antigens: the Potential Receptor for the Rotaviruses

轮状病毒(RVs)是引起婴幼儿及动物非细菌性胃肠炎的重要病原体.研究发现,人类组织血型抗原(HBGAs)可能是RVs的结合受体.HBGAs具有丰富的多态性,包含ABO、分泌型及Lewis抗原.研究表明,不同P型的RVs与HBGAs的结合具有型特异性,而且不同人群对各型RVs易感性存在差异.因此,研究RVs与HBGAs的相互作用对于阐明RV感染的致病机理及RV疫苗的设计具有重要意义.

Rotaviruses（RVs） are one of the most important pathogens for the viral gastroenteritis in human and animals. It is reported that histo-blood group antigens（HBGAs） may be the receptors and/or attachment factors for the RVs. HBGAs are highly polymorphic including ABO, secretor, and Lewis antigens. According to the previous studies, RVs of different P genotypes have been shown to interact with HBGAs in the genotype-dependent manner and there is various RVs susceptibility between different people. Therefore, the research of the interaction between RVs and HBGAs is significant to clarify the mechanism of RV pathogenesis and lays the foundation for the RV vaccine design.