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腭裂相关microRNA与信号通路的相互作用 被引量：7

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摘要 非综合征性唇腭裂是受多因素影响的先天性疾病,其发病机制仍不明确,一直是科学研究的热点。微小RNA（MicroRNA,miRNA）作为一种新型调控小分子,通过与靶基因的特定结合来调控基因的表达,继而影响信号通路的传导。研究发现,胚胎期miRNA在唇、腭等部位特异性表达,提示miRNA可能与颅面部畸形的发生有关。本文主要从腭裂相关的miRNA差异性表达,及其对信号通路的作用、
作者 王鑫 赵尔杨
机构地区 哈尔滨医科大学第一临床医学院.口腔医学院口腔病理科
出处 《口腔医学研究》 CAS CSCD 北大核心 2015年第5期528-530,共3页 Journal of Oral Science Research
基金 李嘉诚全国"重生行动"科研基金项目
关键词 信号通路 MICRORNA 面部畸形 先天性疾病 胚胎期 SMAD 靶向作用 非综合征性腭裂 先天缺陷 腭板
分类号 R782.22 [医药卫生—口腔医学]
  • 相关文献

参考文献21

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共引文献32

同被引文献41

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引证文献7

二级引证文献13

口腔医学研究
2015年 第5期

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