高血压和高血压合并糖尿病患者血浆可溶性VEGFR2与SOD水平的变化

Changes of plasma levels of soluble VEGFR2 and SOD in hypertensive patients and hypertensive diabetic patients

目的:探讨高血压和高血压合并糖尿病患者血浆可溶性血管内皮生长因子受体2(s VEGFR2)与超氧化物歧化酶(SOD)水平的变化。方法:本横断面研究共纳入88人,分为对照组(n=26)、高血压组(n=31)和高血压合并糖尿病组(n=31)。参与者的血压均由水银式血压计测定。人群血浆的s VEGFR2和SOD水平应用酶联免疫吸附法测定,同时检测血糖、糖化血红蛋白A1c(GHb A1c)和血脂的变化情况。结果:单纯高血压组血清总胆固醇(TC)和体重指数(BMI)显著高于对照组(P<0.05),而高血压合并糖尿病组血清TC、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、BMI和腰围(WC)均显著高于对照组(P<0.05)。单纯高血压组和高血压合并糖尿病组血浆s VEGFR2和SOD蛋白表达水平均低于对照组(P<0.05),而高血压合并糖尿病组与单纯高血压组比较血浆s VEGFR2和SOD蛋白表达水平更低(P<0.05)。对整个研究人群进行相关性分析发现,s VEGFR2与SOD之间呈显著正相关(P<0.05)。结论:单纯高血压和高血压合并糖尿病患者血浆s VEGFR2水平均降低,而且高血压合并糖尿病患者血浆s VEGFR2水平降低更明显,SOD水平下降可能与s VEGFR2水平下降有关。

AIM：To explore the changes of plasma levels of soluble vascular endothelial growth factor receptor 2 （ sVEGFR2） and superoxide dismutase （ SOD） in hypertensive patients and hypertensive diabetic patients.METHODS：In this cross-sectional study, 88 cases were enrolled, which were divided into hypertensive group （n=31）, hypertensive diabetic group （ n=31 ） and control group （ n=26 ） .Blood pressure was obtained from each participant with mercury sphygmomanometer.The levels of sVEGFR2 and SOD were measured by ELISA.Meanwhile, the levels of plasma glucose, glycosylated hemoglobin A1c （ GHbA1c） and lipid profile were detected.RESULTS：The levels of total cholesterol （ TC） and body mass index （BMI） were significantly higher in hypertensive group than those in control group （P〈0.05）.The levels of TC, low-density lipoprotein cholesterol （ LDL-C） , triglyceride （ TG） , BMI, waist circumference were significantly higher in hypertensive diabetic group than those in control group （P〈0.05）.The plasma levels of sVEGFR2 and SOD in both hypertensive diabetic group and hypertensive group were significantly decreased compared with control group （ P〈0.05）, while the mean plasma levels of sVEGFR2 and SOD in hypertensive diabetic group were significantly decreased compared to the hypertensive group （ P〈0.05 ） .A significantly positive correlation between sVEGFR2 and SOD in the whole study population （P〈0.05） was observed.CONCLUSION： The plasma level of sVEGFR2 is decreased in both hypertensive and hypertensive diabetic patients, and more significantly decreased in hypertensive diabetic patients.De-creased SOD level may be associated with to the reduction of sVEGFR2.