肠道菌群与肠易激综合征的研究进展

Intestinal flora and irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是胃肠道功能紊乱的一种较为常见的疾病.到目前为止,IBS的发病机制尚不完全清楚,但通过大量的实验研究提示可能与肠道动力障碍、内脏高敏感性、肠道免疫炎症反应及肠道菌群失调等有密切相关性.随着研究的不断深入,发现肠道菌群在IBS疾病的发生发展中扮演着重要角色,本文则从肠道菌群情况与IBS关系的研究现状做一综述.

Irritable bowel syndrome （IBS） is one of the most common gastrointestinal disorders. The pathogenesis of IBS is not fully clear up to now, but numerous studies suggest that it is related to multiple factors, such as abnormal intestinal motility, visceral hypersensitivity, intestinal infection and immunoreaction, and imbalanced intestinal microbiota. The dysbiosis of the gastrointestinal tract microbiota is considered one of the most important factors responsible for the development of IBS. In this article, we will discuss the relationship between intestinal microbiota and IBS.