摘要
炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD),是胃肠道慢性非特异性炎性疾病.目前认为该疾病由多种因素相互作用所致,主要包括环境、遗传、感染和免疫因素,但其病因和发病机制尚未完全明确,加之临床症状不典型,故临床诊断的难度颇大.近年来,基于代谢组学的评价体系用以找寻IBD生物标志物并探讨其发病机制,逐渐成为IBD研究的一种很重要的方法.本文主要介绍代谢组学各类技术方法在研究IBD中的应用,并对其今后的发展趋势作出展望.
Inflammatory bowel disease （IBD）, including ulcerative colitis （UC） and Crohn＇s disease （CD）, is a chronic non-specific inflammatory disorder of the gastrointestinal tract. The etiology and pathogenesis of IBD are still not entirely understood today and are thought to be caused by the interaction of multiple factors, including environmental, genetic, infectious and immune factors. The lack of typical clinical features also leads to a difficult diagnosis of IBD. In recent years, metabonomics is becoming a very important way to find biomarkers and investigate disease mechanisms. In this paper we review the main technologies of metabonomics and their present application in IBD.
出处
《世界华人消化杂志》
CAS
2015年第13期2084-2090,共7页
World Chinese Journal of Digestology
关键词
代谢组学
炎症性肠病
生物标志物
Metabonomics
Inflammatory boweldisease
Biomarkers
