摘要
自噬是一种高度保守的细胞代谢过程,细胞中的蛋白质和细胞器被包裹在自噬体中并运送到溶酶体降解。已发现自噬与神经退行性疾病、肿瘤等多种疾病关系密切,尤其是与肿瘤的关系研究备受关注。自噬在肿瘤的发生、发展中有“双刃剑”作用,即自噬抑制肿瘤的发生但在肿瘤形成后会促进肿瘤发展。肿瘤化疗或放疗过程中会诱导自噬的发生,且一般认为是保护作用。自噬是肿瘤治疗的潜在重要靶标,但由于自噬在肿瘤中的很多作用并未明确,欲通过调控自噬来提高肿瘤疗效尚待更多研究。
Autophagy is an evolutionarily well conserved cellular catabolic process . Cellular proteins and organelles are engulfed to autophagosomes and eventually delivered to lysosomes for degradation .Autophagy is closely associated with a variety of human diseases especially cancer .At present , it has been widely accepted that autophagy is a“double-edged sword” in cancer: it blocks tumorigenesis at the early stage , while it facilitates tumor development at the promotion and progression stage . Moreover , autophagy can be induced by chemotherapy and radiotherapy , which is generally play a pro-survival function .Thus, autophagy is an important target for cancer therapy , and suppression of autophagy to enhance the efficacy of cancer therapeutic agents is a novel strategy in cancer therapy under active clinical trials .
出处
《浙江大学学报(医学版)》
CAS
CSCD
北大核心
2015年第2期204-210,共7页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金(31471297)
关键词
肿瘤
自噬
综述
Neoplasms
Autophagy
Review