帕金森病患者血脂表达情况的研究

Serum Lipid Profile of Patients with Parkinson's Disease

目的:研究帕金森病(PD)患者血脂表达情况,探讨血脂水平对PD患者发生脑卒中的影响。方法:回顾性纳入PD患者、急性脑梗死患者及同期健康体检者各161例,分别为PD组、脑梗组及对照组。比较3组的血脂包括总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及其他因素;以PD组、脑梗组为因变量对2组有统计学差异的变量进一步采用二分类Logistic回归方法分析。结果:PD组TG、LDL-C水平显著低于对照组及脑梗组(均P<0.05),HDL-C水平高于脑梗组(P<0.05);PD组的高血压病、糖尿病患病人数比例低于脑梗组(P<0.05)。二分类Logistic回归分析显示:高水平的HDL-C、低水平的LDL-C、高血压病、糖尿病病史可能与PD人群中脑卒中发生相关。结论:PD患者TG、LDL-C水平低于健康人和脑梗死患者,HDL-C水平高于脑梗死患者。高水平的HDL-C、低水平的LDL-C可能与PD人群中脑卒中发生相关。

Objective：To explore the serum lipid profile of patients with Parkinson’s disease（PD） and the role of the lipids in the occurrence of stroke in PD patients. Methods： A retrospective study was performed on PD patients（PD group, n=161）, healthy controls（HC group, n=161） and acute cerebral infarction patients（CI group, n=161）.The levels of serum lipid profile, total cholesterol（TC）, triglyceride（TG）, low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C）, were compared in the three groups and binary logistic regression was used to analyze the differences of variables in PD and CI groups. Results： The TG and LDL-C levels were significantly lower in the PD group than those in the HC group and CI group（P〈0.05）. The LDL-C level was higher in the PD group than that in the CI group（P〈0.05）. The occurrence of patients with hypertension and diabetes in the PD group was lower than those in the CI group（P〈0.05）. Binary Logistic regressions showed that HDL-C, LDL-C, history of hypertension and diabetes were risk factors of the occurrence of stroke in PD patients.Conclusion： PD patients show lower levels of TG and LDL-C and higher HDL-C level than those in acute cerebral infarction patients. High level of HDL-C and low level of LDL-C may be risk factors of stroke in PD patients.