摘要
目的:探讨短暂性全面性遗忘(TGA)的诊断、发病部位、病因及发病机制。方法:收集一例TGA患者的病史、临床表现、神经心理学检查和神经影像学资料。结果:该患者无脑血管病的危险因素及神经科疾病的病史,临床表现为一过性顺行性情景记忆障碍,神经心理学检查提示词语再认障碍,头颅MRI的液体衰减反转恢复序列、MR扩散加权成像序列在海马CA1区显示高信号。结论:TGA的发病部位在海马CA1区,其发病机制可能为应激诱发海马CA1区一系列病理生理的级联反应,导致海马神经元的急性细胞性水肿。
Objective： To investigate the diagnosis, pathological location and the pathophysiology of transient global amnesia（TGA）. Methods： The history, clinical presentations, neuropsychological examinations and neuroimaging data of the TGA patient were collected. Results： The patient had no risk factors of cerebrovascular disease and had no the other neurological diseases, had a transient anterograde amnesia, had the disorder in word recognition and the increased signals of the CA1 field of the hippocampal cornu ammonis（CA） in the DWI and T2 FLAIR of brain MRI. Conclusioin： The hippocampal CA1 neurons is the lesion location of TGA. Stress can play a key role in the pathophysiological cascade, leading to an acute cytotoxic edema of hippocampal CA1 neurons during TGA.
出处
《神经损伤与功能重建》
2015年第3期226-228,共3页
Neural Injury and Functional Reconstruction
