成人隐匿性自身免疫性糖尿病诊治的相关研究进展

Diagnositic and therapeutic progress of latent autoimmune diabetes in adult

LADA属于T1DM,其早期表现类似T2DM。LADA在新诊断T2DM患者中发病率为10%。国内外公认的LADA诊断要点为成年起病、存在胰岛自身抗体和诊断后至少6个月不依赖胰岛素治疗。其中,胰岛自身抗体是诊断LADA的重要指标。基因、非胰岛细胞的自身抗体和细胞免疫标志可能成为新的辅助诊断依据。早期应用胰岛素可能对部分LADA患者胰岛细胞有保护作用。

LADA presenting with a similar phenotype of T2 DM at early stage,belongs to the slowly progressive subtype of autoimmune T1 DM.The proportion of LADA in newly diagnosed T2 DM is about 10%.Recognized LADA diagnosis points mainly include：adult onset,autoantibody of islets,and no relying on insulin therapy at least six months after diagnosis.Therein,autoantibody of islets is important index in diagnosing LADA.Genes,other autoantibodies and cellular immune markers are expected to become the new diagnosis basis.For some LADA patients,treatment with insulin earlier may have protective effect on islet cell function.