我院住院患者抗菌药物联合应用调查与研究

An Analysis and Probe into Inpatients' Combined Application of Antibiotics in our Hospital

目的研究该院住院患者抗菌药物联合使用情况,发现和纠正不合理联合用药现象,以促进临床合理用药。方法随机抽取该院2013年10月住院患者病历,采用回顾性调查方法 ,从中筛取使用抗菌药物的病历共288份,其中联合用药病例共225份,统计出每份病历联合用药方式、品种及主要病症情况。结果抗菌药物联合用药病历占使用抗菌药物病历的78.13%。其中以二联用药为主,合理联合用药占联合用药病历的88.00%。不合理联合用药中无指征用药占多数,比例占不合理联合用药的44.44%,药效学配伍禁忌占37.04%,药动学配伍禁忌占18.52%。结论掌握抗菌药物联合用药适应证及药物之间相互作用等特征,才能使联合用药疗效增强。

Objective This paper aims to delve into the inpatients’ combined application of antibiotics in our hospital, and to discover and correct improper combined medication and promote proper clinical medication. Methods Inpatients＆#39; medical records from our hospital in October, 2013 were randomly selected and a retrospective investigation approach was adopted to select 288 case with antibiotics medication, in which 225 are of combined medication. The way and category of combined medication, main symptoms were gain of each department.Results Combined medication in these three departments were found 78.13% of the total antibiotics application. The most frequently used is two kinds combined medication, Among them, 88.00 % are of proper application where 44.44% are no-indication medication, 37.04% are pharmacodynamic incompatibility and 18.52% are pharmacokinetic incompatibility. Conclusion Only we master the adaptive disease of antibiotics application and interaction of different drugs can we make combined medication proper and reinforce effects.