用于光热治疗的金/介孔纳米材料的制备与研究

The preparation of MSN@ Au nanomaterials and photothermal therapy of cancer cells

目的研究金纳米颗粒包覆的介孔硅二氧化硅(MSN@Au)的制备方法,合成后的MSN@Au纳米材料具有光热抗肿瘤作用。方法以材料对卵巢癌(Hela)细胞的抑制率作为评价指标,综合考察自制的纳米材料的抗肿瘤作用。结果合成的MSN纳米颗粒粒径均一、分散性良好,均匀吸附金纳米颗粒后的材料利用808 nm NIR照射3 min后,癌细胞存活率只有50%以下。结论制备出的MSN@Au纳米材料,利用NIR照射后,能在肿瘤细胞局部产热,杀伤肿瘤细胞,对肿瘤细胞有热疗作用。

Objective To optimize the preparation of MSN@Au nano-materials for the photothermal therapy of cancer cells.Method According to the inhibition growth of Hela cells,we evaluate the photo-thermal antitumor effects of the MSN@Au nanomaterials.Re-sults MSN own uniform particle size and good dispersibility.When Hela cell are exposed to MSN@Au nano-materials,cell vibiality is 50% or less after irradiation to NIR laser （808 nm,3 min）.Conclusion Local heating mediated with the MSN@Au nano-materials and NIR laser could be used for antitumor photothermal therapy.