胎盘源细胞治疗急性辐射骨髓衰竭研究

The Effect of Placentas Derived Cells Treatment on Acute Radiation Bone Marrow Failure

核辐射易造成人体造血系统损伤,为此建立急性辐射骨髓衰竭小鼠模型,通过单次腹腔注射异基因小鼠多份不同胎盘源细胞/细胞因子,明确其治疗急性辐射骨髓衰竭的疗效.实验将造模后小鼠随机分为胎盘源细胞治疗组、胎盘源细胞因子治疗组、胎盘源细胞联合细胞因子治疗组以及模型小鼠对照组4组,治疗后统计分析各组小鼠存活时间.结果表明,胎盘源细胞联合细胞因子可有效延缓急性辐射骨髓衰竭小鼠的寿命(P<0.05).

Nuclear radiation results easily in the damage of hematopoietic system in human body.Because of that,the mouse models for acute radiation bone marrow failure were formed.The allogene mouse placentas derived cells/cytokine were intraperitoneally injected into acute radiation bone marrow failure model mice with single time in order to identify its therapeutic effect.Model mice were separated into placentas derived cells treatment group,placentas derived cytokine treatment group,placentas derived cells combined with cytokine treatment group and model mice control group at random to analyze their survival time after treatment.The result shows placentas derived cells combined with cytokine treatment can prolong effectively acute radiation bone marrow failure mice survival time (P <0.05).