摘要
年龄相关性黄斑变性(age-related macular degeneration,AMD)是一种常见于50岁以上人群的慢性进行性退化的黄斑疾病,是发达国家老年人视力丧失的主要原因。在我国随着人口老龄化的到来,该病的发病率也逐年上升,但其发病机制尚不明确。最新研究表明,眼局部具有独立形成肾素-血管紧张素系统(rennin-angiotensin system,RAS)的能力,并且多项研究表明RAS在AMD的早期和晚期均直接参与了疾病的发生发展,在AMD的发病过程中起到了重要作用,本文就关于RAS在AMD中的作用机制做一简要综述。
Age-related macular degeneration （AMD） is a chronic progressive macular disease that occurs mostly in people over the age of 50, which is the main eye disease that causes loss of vision in the elderly in developed countries. Along with coming of aging population in our country, the incidence of AMD is increasing, but its pathogenesis is still unclear, the latest research shows that eye tissues are with independent synthetic renin-angiotensin system （RAS） capabilities, besides numbers of studies have shown that the RAS in early and late AMD were directly involved in the disease development and played an important role in the pathogenesis, this paper gives a brief review of research progress on mechanism of RAS in AMD.
出处
《国际眼科杂志》
CAS
2015年第6期997-999,共3页
International Eye Science
