性病门诊泌尿生殖道支原体感染情况及耐药趋势分析

STD Analysis of Mycoplasma Infection and Drug-resistance Trends

目的分析性病门诊泌尿生殖道解脲脲原体(UU)和人型支原体(Mh)感染情况及耐药趋势。方法对本院2010年8月-2014年8月性病门诊收治的4 229例疑诊为泌尿生殖道支原体感染患者进行支原体培养和鉴定,并采用药敏试剂盒进行解脲脲原体和人型支原体耐药趋势检测。结果单纯解脲脲原体对交沙霉素、克拉霉素以及罗红霉素的耐药率分别为1.04%,5.10%和5.19%,总体耐药率较低;单纯人型支原体感染对交沙霉素、多西环素、四环素的耐药率分别为0,2.63%和7.89%,耐药率也较低;而混合感染解脲脲原体和人型支原体对环丙沙星和红霉素耐药率分别为84.00%和73.33%,耐药率较高。该两者耐药趋势差异无统计学意义(P>0.05)。结论解脲脲原体是性病门诊中泌尿生殖道支原体感染的主要病原体,交沙霉素和多西环素对支原体混合感染有很好的药效,可作为首选治疗药物。

Objective To analyze urogenital Ureaplasma urealyticum （UU） and Mycoplasma hominis （Mh） infections, and drug-resistance trends in STD clinic. Methods Mycoplasma culture and pathogen identification were performed in 4 229 cases with suspected mycoplasma infections in our STD clinic from August 2010-August 2014. Sensitivity test kits were used to detect the sensitivity of UU and Mh to drugs, and to assess their drug-resistance trends. Results For UU infection alone, the resistance rates to antibiotics were low （ 1.04% to josamycin, 1.04% to clarithromycin and 5.19% to roxithromycin）. In Mh infection, the resistance rates of Mh to antibiotics were also low （0% to josamycin, 2.63% to doxycycline, and 7.89% to tetracycline）. In contrast, in patients infected by both UU and Mh, resistance rates to ciprofloxacin and erythromycin were 84.00% and 73.33% , respectively （P 〉 0.05）. Conclusion UU is the major pathogen of mycoplasma infection in STD clinic. Josamycin and doxycycline are effective for mixed infections of UU and Mh. These drugs could be the first choice for the mixed infections.