低分子右旋糖酐联合速尿持续静脉滴注治疗小儿肾病综合征水肿50例

Clinical Effect of Low Molecular Dextran Combined with Continuous Intravenous Drip of Furosemide for Treating Nephrotic Syndrome Edema in Children

目的探讨低分子右旋糖酐联用速尿持续静脉滴注治疗小儿肾病综合征水肿的效果。方法将收治的小儿肾病综合征水肿患儿100例按随机数字表法分成对照组和观察组,各50例。在常规治疗基础上,对照组患儿给予速尿静脉注射;观察组患儿使用低分子右旋糖酐联合速尿静脉滴注。结果观察组总有效率为100.00%,明显优于对照组的70.00%(P<0.05);观察组水肿消退时间(15.8±4.1)h、血清白蛋白升高时间(7.7±1.2)d、多尿时间(3.4±1.2)h,对照组分别为(28.3±12.1)h,(12.5±1.3)d,(14.1±2.5)h,观察组较对照组显著缩短(P<0.05);观察组尿蛋白和血清胆固醇较对照组均显著降低,而观察组血清白蛋白水平较对照组显著升高(P<0.05);观察组水肿复发率为6.00%,明显低于对照组的42.00%(P<0.05)。结论低分子右旋糖酐联用速尿持续静脉滴注治疗小儿肾病综合征水肿,效果突出,不良反应少,值得推广。

Objective To investigate the effect of low molecular dextran combined with continuous intravenous drip of furosemide for treating nephrotic syndrome edema in children.Methods 100 children patients with nephrotic syndrome edema in ourhospital were divided into the control group and the observation group according to the random number table method,50 cases in each group.On the basis of conventional treatment,the control group was given furosemide by intravenous injection; the observation group was given low molecular dextran plus furosemide by intravenous drip.Results The total effective rate after treatment in the observation group was100%,which was obviouslyhigher than 70% in the control group,the difference was statistically significant（P〈0.05）; the edema subsiding time was（15.8 ± 4.1）h in the observation group,the serum albumin increase time was（7.7 ± 1.2） d and the polyuria time was（3.4 ± 1.2）h,which were significantly shorter than（28.3 ± 12.1）h,（12.5 ± 1.3） d and（14.1 ± 2.5） in the control group respectively,the differences were statistically significant（P〈0.05）.The urine protein and serum cholesterol levels in the observation group were significantly decreased compared with those in the control group,while the level of serum albumin in the observation group was significantly increased compared with that in the control group,the difference was statistically significant（P〈0.05）; the edema recurrence rate in the observation group was significantly decreased compared with the control group,the difference was statistically significant（6% vs.42%,P〈0.05）.Conclusion Low molecular dextran combined with continuous intravenous drip of furosemidehas prominent effect and less adverse reactions in the treatment of children with nephrotic syndrome edema,and is worthy of popularization and application.