维胺酯在大鼠体内的血药浓度及组织分布

目的：研究SD大鼠口服维胺酯（Via）后体内的血药浓度及组织分布情况。方法大鼠口服Via后，通过高效液相色谱检测各时间点血浆和组织中药物浓度，采用DAS2.0软件进行房室模型拟合并计算药物动力学参数。结果大鼠口服Via125 mg/kg，所得血浆药时曲线符合二室模型，主要药代动力学参数：t1/2（β）为（2.22±0.52）h；Tmax为（0.83±0.13）h；Cmax为（3.90±1.05）mg/L。Via口服后15min内可迅速分布至各主要组织器官，1 h后药物在脂肪组织浓度最高，皮肤、肌肉组织次之，骨骼最低。7 h后各组织药物浓度均明显下降。结论 Via在体内吸收迅速、清除较快、分布广泛，在脂肪和皮肤组织中浓度最高。

Objective To study the plasma concentration and tissue distribution of oral viaminate in rats. Methods The plasma and tissue concentrations of viaminate were detected by high performance liquid chromatography at various times after oral administration in rats. The pharmacokinetic parameters were calculated with Das2.0 program. Results The time-concentration curve of viaminate corresponded to the model of two-compartment model after oral administration. The main pharmacokinetics parameters were：t1/2（β）=（2.22 0.52）h;Tmax=（0.83±0.13） h;Cmax=（3.90±1.05）mg/L. It was showed that viaminate was absorbed rapidly and was distributed in many tissues or organs in 15minutes.The concentration of viaminate was highest in fat at 1 h,followed by skin and muscle,lowest in skeleton. The concentrations in all of the tissues were decreased obviously. Conclusions Viaminate can be quickly absorbed and distributed in various tissues or organs in vivo, fellowed by being eliminated very quickly. The concentration of viaminate in skin and fat is higher than that in other tissues.