海藻糖在生育力保存中的应用

Application of Trehalose in Fertility Preservation

肿瘤诊疗技术的进步显著提高了患者的生存率,但放化疗可能造成人类生育力的下降乃至丧失。如何有效保存生育力已成为近年来研究的热点。海藻糖属于非渗透性冷冻保护剂,是一种具有特殊生物学性能的双糖,能够在干燥、脱水、冷冻等恶劣条件下有效保护蛋白质等大分子不变性失活。随着研究的逐步深入,海藻糖已被广泛应用于生育力保存等医学领域中,有学者将其用于保存精子、精原干细胞、卵母细胞、胚胎、卵巢组织和睾丸组织并取得了显著成果。综述海藻糖的生物学性质、作用机制假说以及在生育力保存中的应用研究现状和最新进展。

The survival rate of cancer patients has been greatly improved with the advance in diagnosis and treatment technology, however, their fertility is damaged, even lost, by the radiotherapy and chemotherapy. How to effectively preserve fertility is a hot issue in recent years. Trehalose, a disaccharide with special biological properties,is used as a non-permeable cryopmtectant which effectively protect the activities of proteins and other macromolecules in a dry,dehydration,freezing and other harsh conditions. With the research progress, trehalose has been widely used in the medical field, such as the preservation of fertility. Some scholars tried to use it for saving sperm, spermatogonial stem cells, oocytes, embryos, ovarian tissue and testicular tissue, and achieved remarkable results. This review focuses on the biological properties of trehalose,potential mechanism and the research progress of its application in fertility preservation.