期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

维生素D受体ApaI和FokI位点基因多态性和种植体周围炎的相关性研究

Investigation on the relationship between gene polymorphisms of vitamin D receptor(Apa I, Fok I) and peri-implantitis
原文传递
导出
摘要 目的探讨维生素D受体(vitamin D receptor,VDR)Apa I和Fok I位点基因多态性和种植体周围炎是否具有相关性。方法采用病例对照试验设计,种植体周围炎组及健康对照组各65例,应用聚合酶链反应-限制性内切酶片段长度多态性分析方法研究2组VDR Apa I和Fok I位点的基因型以及等位基因分布特点,并探讨其与种植体周围炎的相关性。结果两组VDR基因Apa I位点和Fok I位点各基因型以及等位基因频率分布差异无统计学意义。结论排除吸烟、牙周炎病史等影响因素后,尚未发现VDR Apa I位点和Fok I位点基因多态性在种植体周围炎发生中发挥着重要作用。 Objective To investigate the association between the genetic polymorphism of vitamin D receptor （ApaI, FokI） and peri-implantitis. Methods The subjects were divided into peri-implantitis group and control healthy group, with 65 cases for each group. The case-control trial was used in this study. Polymerase chain reaction-restriction fragment length polymorphism was applied to analyze the genotype of vitamin D receptor （ApaI, FokI）, the characteristics of distribution, and correlation with peri-implantitis. Results There were no siginificant differences in genotypes or allele frequencies of VDR genotypes（ApaI, FokI） between peri-implantitis groups and control group. Conclusion VDR genetic polymorphism （ApaI, FokI） do not paly important roles in the development of peri-implantitis excluding some influence factors, such as smoking and periodontitis.
作者 刘琼 黄建生 卿玲 谢宇 张宇婕
机构地区 南方医科大学附属口腔医院.广东省口腔医院特诊中心
出处 《现代口腔医学杂志》 CAS CSCD 2015年第3期153-156,共4页 Journal of Modern Stomatology
关键词 维生素D受体 基因多态性 种植体周围炎 Vitamin D Receptor Genetic polymorphism Peri-implantitis
分类号 R783.6 [医药卫生—口腔医学]
  • 相关文献

参考文献17

  • 1Mir-Mari J, Mir-Orfila P, Figueiredo R, et al. Prevalence of peri-implant diseases. A cross-sectional study based on a private practice environment. J Clin Periodontol, 2012, 39(5): 490-494.
  • 2ES, Cho SC, Elian N, et al. A comparison of characteristics of im-plant failure and survival in periodontally compromised and periodontally healthy patients: A clinical report. Int J OralMaxil-lofac Implants, 2004, 19(6): 873-879.
  • 3Eser Elemek, B.D.S; Khalid Almas,B.D.S. Peri-implantitis: etiology, diagnosis and treatment. The New York State Dental Journal, 2014, 80(1): 26-31.
  • 4Kozlovsky A, Tal H, Laufer BZ, et al. Impact of implant overloading on the peri-implant bone in inflamed and non- inflamed peri-implant mucosa. Clin Oral Impl Res, 2007, 18 (5): 601-610.
  • 5Grtissner-Schreiber B, Teiehmann J, Hannig M, et al. Modified implant surfaces show different biofilm compositions under in vivo conditions. Clin Oral Implants Res,2009, 20 (8): 817- 826.
  • 6Heitz-Mayfield LJ. Diagnosis and management of peri-implant diseases. Aust Dent J, 2008, 53 Suppl 1: $43-$48.
  • 7Spector TD, Keen RW, Arden NK, et al. Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain. BMJ, 1995, 310 (6991): 1357-1360.
  • 8Morrison NA, Yeoman R, Kelly PJ, et al. Contribution of trans- acting factor alleles to normal physiological varlability:vitamin D receptor gene poiymorphism and circulating osteocalcin. Proc Natl Acad Sci USA, 1992, 89(15): 6665-6669.
  • 9Famih P, Cauley J, Suzuki JB, et al. Longitudinal study of periodontal disease and edentulism with rates of bone loss in older women. J Periodontol, 2005, 76(1): 11-15.
  • 10Plagnat D, Giannopoulou C, Carrel A, et al. Elastase, alpha2- macroglobulin and alkaline phosphatase in crevicular fluid from implants with and without periimplantitis. Clin Oral ImplantsRes, 2002, 13(3): 227-233.

二级参考文献18

  • 1文格波,曹仁贤.甲状腺肿瘤p53mRNA及p53蛋白表达的研究[J].中国组织化学与细胞化学杂志,1997,6(2):96-99. 被引量：3
  • 2杨泓,朱冬梅,陈娜.种植体周围炎[J].伤残医学杂志,2004,12(3):39-41. 被引量：4
  • 3Adell R, Eriksson B, Lekholm U, et al. Long-term follow-up study of osseoinlegrated implants in the treatment of totally edentulous jaws. Int J Oral Maxillofac Implants, 1990.5 (4) :347-359.
  • 4Schwarz MS. Mechanical complications of denial implants. Clin Oral Implants Res. 2000. 11( Supp 1): 156-158.
  • 5Alvim-Pereira F, Montes CC, Thome G, et al. Analysis of association of clinical aspects and vitamin D receptor gene polymorphism with dental implant loss.Clin Oral Implants Res, 2008,19(8) :786- 795.
  • 6heitz-Mayfield L J. Diagnosis and management of pen-implant diseases. Aust Dent J, 2008,53(Supp 1):S43-S48.
  • 7Albrektsson TO, Johansson CB, Sennerby L. Riological aspects of implant deatistry: osseointegration. Periodontol 2000,1994,4:58-73.
  • 8Esposito M, Dirsch J M, Lekholm U, et al. Biological factors contrhuting to failures of osseointegrated and implants(1).Suceess eritetia and epidemiology. Eur J Oral Sci,1998,106(1):527-551.
  • 9Suarez F, Zeghoud F, Rossignol C, et al. Association hetween vitamin D reveptor gene polymorphism and sevdependent growth during the first two years of life. J Clin Endoerinol Metab, 1997,82(9)2966-2970:.
  • 10Minamitani K. Takahashi Y, Minagawa M, et al. Difference in height associated with a translation start site polymorphism in the vitarain D receptor gene. Pediatr Res, 1998,44(5) :628-632.

共引文献5

现代口腔医学杂志
2015年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部