白细胞介素23受体基因单核苷酸多态性与肺结核和耐药肺结核易感性的相关性

Polymorphisms of IL-23 receptor gene are associated with susceptibility to pulmonary tuberculosis and drug-resistant pulmonary tuberculosis

目的 探讨白细胞介素（IL）-23受体基因单核苷酸多态性与肺结核和耐药肺结核易感性的相关性.方法 采用配对病例对照研究方法,用SNaPshot技术,对2013年10月至2014年4月新疆喀什地区肺科医院收治的250例新疆维吾尔族痰结核分枝杆菌培养阳性的肺结核患者（病例组）和同期250名健康体检者（对照组）的IL-23受体基因全部外显子及部分邻近内含子区的13个单核苷酸多态性位点的基因型进行检测,分析基因型、等位基因和单体型与肺结核易感性的关系.结果 IL-23受体基因的rs10889677和rs7518660与新疆维吾尔族人群肺结核的易感性相关（OR=1.53,95％CI：1.01-2.31;OR =6.25,95％CI：3.85-10.00）,rs11465802与耐药肺结核的发生相关（OR=2.90,95％ CI：1.69-4.98）.结论 IL-23受体基因的rs10889677和rs7518660可能是新疆维吾尔族人群肺结核发生的危险因素,rs11465802可能是耐药肺结核发生的危险因素.

Objective To explore the associations of interleukin-23 （IL-23） receptor gene polymorphisms,susceptibility to pulmonary tuberculosis and drug-resistant pulmonary tuberculosis （TB）.Methods For this paired case-control study,13 single nucleotide polymorphisms （SNPs） in IL-23R gene were genotyped by multiplex SNaPshot with samples from 250 pairs of culture positive pulmonary TB patients and healthy controls.And the relationship between genotype,allele,haplotype and susceptibility to pulmonary tuberculosis was analyzed.Results Two SNPs of IL-23R gene （rs10889677 and rs7518660） （OR =1.53,95% CI：1.01-2.31;OR =6.25,95% CI：3.85-10.00） were significantly associated with susceptibility to pulmonary TB and one SNP （rs11465802） （OR =2.90;95% CI：1.69-4.98） was associated with drug-resistant pulmonary TB in the Chinese Uygur population.Conclusions Two SNPs of IL-23R gene,rs10889677 and rs7518660,may be the risk factors of pulmonary tuberculosis.And rs11465802 may be a risk factor of drug-resistant pulmonary tuberculosis in Chinese Uygur population.