新疆地区96例维族恶性黑素瘤临床特征及预后分析

Clinical and prognostic analysis of 96 patients with malignant melanoma in Xinjiang Region

分析新疆地区维族恶性黑素瘤(MM)的临床及影响预后的因素。96例维族MM患者平均发病年龄为55.1±14.3岁,男女比为1.3:1,肢端为最常见的发病部位;淋巴结为最常见的转移部位,32例患者发生淋巴结转移;46例(47.9%)患者伴有原发病灶溃疡。存活时间中位数为38个月,5年生存率为37%。年龄、发病部位、是否溃疡、Clark分级、AJCC分期、BRAF基因突变与预后相关(P<0.05),而性别、是否淋巴结转移与预后不相关(P>0.05)。

The clinical data of 96 patients （54 males, 42 females） with malignant melanoma in Xinjiang Region were analyzed. The average age of the patients at onset was 55.1 ± 14.3 years. The most frequent loca- tion of the lesion was acra. Lymph node was the most frequent metastatic site which was seen in 32 patients. The lesion was ulcerated in 46 patients. The median survival time was 38.0 months. The 5-year survival rate was 37%. Statistical analysis showed that the prognosis of MM was correlated with age, site, ulcer, postopera- tive tumor margin, AJCC staging, Clark classification, treatment method and BRAF mutation （P〈0.05） and was uncorrelated with gender and lymph node metastasis （P〉0.05）.