臭椿树根化学成分研究

Chemical constituents from roots of Ailanthus altissima

目的研究臭椿Ailanthus altissima根部的化学成分。方法采用硅胶柱色谱和HPLC等分离方法,对臭椿树根正己烷萃取物的化学成分进行分离,并经波谱数据分析鉴定结构。结果分离得到了14个化合物,分别鉴定为20β-羟基达玛烷-24-烯-3-酮(1)、β-谷甾醇(2)、ocotillone(3)、5,6,7,8-四甲氧基香豆素(4)、尼洛替星(5)、isofouquierone peroxide(6)、20S,24S-二羟基达玛烷-25-烯-3-酮(7)、匹西狄醇A(8)、eichlerianic acid(9)、二氢尼洛替星(10)、12β,20β-二羟基达玛烷-24-烯-3-酮(11)、铁屎米-6-酮(12)、12β-hydroxy ocotillone(13)、20S,25-epoxy-24R-hydroxy-3-dammaranone(14)。结论化合物3、4、6、9、10、13系首次从该植物中分离得到。

Objective To study the chemical constituents from the roots of Ailanthus altissima. Methods Compounds were isolated and purified by silica gel column chromatography and HPLC, and their structures were identified by spectral analysis. Results Fourteen compounds were isolated and identified as 20-hydroxydammar-24-en-3-one （1）, D-sitosterol （2）, ocotillone （3）, 5,6,7,8-tetramethoxycoumarin （4）, niloticin （5）, isofouquierone peroxide （6）, 20S,24S-dihydroxydammar-25-en-3-one （7）, piscidinol A （8）, eichlerianic acid （9）, dihydroniloticin （10）, dammar-24-ene-12β,20β-diol-3-one （11）, canthin-6-one （12）, 12β-hydroxy ocotillone （13）, and 20S,25-epoxy-24R-hydroxy-3-dammaranne （14）. Conclusion Compounds 3, 4, 6, 9, 10, and 13 are isolated from this plant for the first time.