创伤后肘关节异位骨化研究进展

RESEARCH PROGRESS OF HETEROTOPIC OSSIFICATION OF ELBOW JOINT AFTER TRAUMA

目的综述创伤后肘关节异位骨化研究进展。方法查阅近年国内外有关创伤后肘关节异位骨化相关研究文献,并进行总结分析。结果创伤后肘关节异位骨化发生机制主要与BMP信号转导失调有关。目前临床对其治疗方法较多,包括非手术治疗、预防以及手术治疗。非手术治疗及预防主要针对创伤后肘关节未形成异位骨化或异位骨化致肘关节活动轻度受限的患者,包括药物治疗、放射治疗、中医中药治疗、康复治疗等。对于非手术治疗无效的患者,需选择手术治疗。手术治疗主要包括切开松解术、关节镜下松解术以及关节置换,其中以切开松解术为主。结论肘关节异位骨化临床常见,目前尚无一种公认的标准治疗方案,综合使用非手术治疗和手术治疗方案是今后治疗方向。

Objective To summarize the research progress of heterotopic ossification of the elbow joint after trauma. Methods The recent domestic and foreign literature concerning heterotopic ossification of the elbow joint after trauma was analysed and summarized. Results The mechanism of heterotopic ossification of the elbow joint after trauma is mainly related to bone morphogenetic protein signal transduction disorder. Now there are many treatments of heterotopic ossification, including non-surgical treatment, prevention, and surgical treatment. Non-surgical treatment and prevention mainly aim at patients who have no elbow heterotopic ossification or who have mild limited elbow motion because of elbow heterotopic ossification after trauma, including drug therapy, radiation therapy, Chinese medicine therapy, and rehabilitation treatment. For patients with invalid non-surgical treatment, choosing surgical treatment is a must. Surgical treatment includes surgical resection, arthroscopic resection, and joint replacement, priority should be given first to surgical resection. Conclusion Heterotopic ossification of the elbow joint is common and there is not a recognized standard treatment, comprehensive use of non-surgical treatment and surgical treatment is the future direction.