胱抑素C联合尿微量白蛋白在高血压肾病中的诊断价值

目的探讨胱抑素C(Cys C)联合尿微量白蛋白(m ALB)在高血压肾病中的诊断价值。方法选取高血压患者20例作为观察组,选取30名健康人群作为对照组,检测并比较2组人群的Cys C、尿m ALB和血Cr水平。结果 2组血Cr分别为(63.9±21.1)μmol/L和(78±21)μmol/L,差异具有统计学意义(P<0.05);2组Cys C分别为0.79 mg/L和1.38 mg/L,差异具有统计学意义(P<0.05);Cys C诊断高血压肾病的价值显著高于m ALB和Cr(P<0.05);高血压患者中血Cys C与血Cr联合诊断阳性率为50%,尿m ALB联合诊断阳性率是80%,Cys C与尿m ALB组合诊断高血压肾病的价值差异具有统计学意义(P<0.01)。结论 Cys C联合尿m ALB组合可明显提高高血压肾病检测率,值得在临床推广应用。

Objective To explore the value of cystatin C（Cys C） combined with urinary microalbumin （mALB） in the diagnosis of hypertensive nephropathy. Methods 20 cases （from January 2013 to August 2014） of hypertensive patients were selected from our hospital as the observation group, and 30 cases of healthy people were selected as the control group. The levels of Cys C, mALB and Cr were detected and compared. Results The level of Cr of two groups were （63.9±21.1）μmol/L and （78±21）μmol/L, which was statistically different （P〈0.05）;The level of Cr of two groups were 0.79 mg/L and 1.38 mg/L, which was statistically different （P〈0.05）;the value of Cys C was higher than that of mALB and Cr （P〈0.05）;the positive diagnostic rate of Cys C combined with Cr was 50%and that of Cys C combined with mALB was 80%, which was statistically different （P〈0.01）. Conclusion The combination of Cys C and mALB can effectively improve the detection rate of Hypertension Nephropathy, and it is worthy of clinical application.