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血管内皮生长因子与抑郁症关系的临床研究进展 被引量：2

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摘要 抑郁症是精神障碍中常见的一种疾病，其终生患病率约10％．自杀率高达15％：神经营养假说认为，脑内神经营养因子的不足会对神经系统的结构或功能造成影响，血管内皮生长因子（vascular endothelial growth factor，VEGF）是一种重要的神经营养因子，相对分子量34～45kDa，主要由神经细胞、神经胶质细胞及炎症细胞产生，具有促进神经细胞生长、保护神经细胞、增强突触可塑性等作用，并有望成为治疗抑郁症的新分子靶点。
作者 张庆玉 王训强 楼忠泽 季蕴辛 阮列敏
机构地区 宁波大学医学院 宁波市第一医院心身科
出处 《浙江医学》 CAS 2015年第10期901-903,共3页 Zhejiang Medical Journal
基金 浙江省医药卫生一般研究项目(2011KYB098)
关键词 血管内皮生长因子 抑郁症 临床研究 神经营养因子 神经细胞生长 神经胶质细胞 终生患病率 相对分子量
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献29

  • 1Howell K R, Kutiyanawalla A, Pillai A, et al. Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex[J]. PLoS One, 2011,6(5): e20198.
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  • 3Berent D, Macander M, Szemraj J, et al. Vascular endothelial growth factor A gene expression level is higher in patients with major depressive disorder and not affected by cigarette smoking, hyperlipidemia or treatment with statins[J]. Acta Neurobiol Exp (Wars), 2014, 74(1): 82-90.
  • 4Clark-Raymond A, Meresh E,Hoppensteadt D, et al.Vascular En-dothelial Growth Factor: A potential diagnostic biomarker for ma- jor depression[J]. J Psychiatr Res, 2014,59:22.
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二级参考文献34

  • 1孙学礼.难治性抑郁障碍及其药物治疗[J].中国处方药,2006(10):9-13. 被引量：10
  • 2Plouet J, Moro F, Bertagnolli S, et al. Extracellular cleavage of the vascular endothelial growth factor189 - amino acid form by u- rokinase is required for its mitogenic effect [ J 3. J Biol Chem, 1997, 272(20) : 13390 - 13396.
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  • 10Sen S, Duman R, Sanacora G. Serum brain - derived neurotrophic factor, depression, and antidepressant medications: meta- analyses and implications [ J ]. Biol Psychiatry, 2008,64 ( 6 ) : 527 - 532.

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浙江医学
2015年 第10期

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