血清CEA、CA199、CA125和SF对结肠癌化疗效果的评估价值

Values of serum CEA,CA199,CA125 and SF for predicting the efficacy to chemotherapy in advanced colon cancer

目的 :评价联合检测晚期结肠癌患者血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)和铁蛋白(SF)在化疗疗效评估中的价值。方法:测定晚期结肠癌63例患者化疗前、化疗1周期后血CEA、CA199、CA125、SF的水平;并在化疗2周期后进行疗效评价。结果 :(1)血清CEA、CA199、CA125、SF4项指标:有效组化疗前分别为72.3±130.7ng/m L、101.3±134.0U/m L、58.4±76.3U/m L、88.7±79.5μg/L,化疗后94.3ng/m L、65.7±109.0U/m L、27.4±18.1U/m L、54.8±43.8μg/L;进展组化疗前分别为82.5±122.8ng/m L、93.2±91.1U/m L、115.1±127.1U/m L、142.0±98.2μg/L,化疗后165.9±170.3ng/m L、206.8±163.9U/m L、127.4±120.0U/m L、143.2±98.0μg/L;稳定组化疗前分别为34.4±87.7ng/m L、78.8±143.7U/m L、24.8±20.4U/m L、118.3±91.4μg/L,化疗后42.1±116.3ng/m L、97.9±190.7U/m L、29.3±40.9U/m L、139.1±102.9μg/L。化疗有效组化疗后浓度均较化疗前明显下降(P<0.05);进展组化疗后浓度均较化疗前明显升高(P<0.05);稳定组化疗前后没明显变化(P>0.05)。多重回归分析显示,血清CEA、CA199、CA125浓度变化与化疗效果相关,有统计学意义,而血清SF与化疗效果相关性无统计学意义(t=1.822,P=0.074)。血清肿瘤标志物水平变化与化疗效果相关性由大到小依次为CEA、CA199、CA125和SF。结论:血清CEA、CA199、CA125水平变化与结肠癌化疗效果相关,其检测对评估化疗效果有一定的价值。

Objective：To investigate the values of serum carcinoembryonic antigen（CEA）,carbohydrate antigen 19-9 （CA199）,carbohydrate antigen 125 （CA125） and ferritin （SF） determination in assessing the effect of chemotherapy in pa-tients with advanced colon cancer. Methods：The concerntrations of serum CEA,CA199,CA125 and SF for 63 patients with advanced colon cancer were determined,before and after 1cycle of chemotherapy and the effect of chemotherapy was evalu-ated after 2 cycles of chemotherapy. Results：In effective group serum concentrations of CEA,CA199,CA125 and SF were 72.3 ±130.7ng/mL、101.3 ±134.0U/mL、58.4 ±76.3U/mL、88.7 ±79.5μg/L before chemotherapy respectively,they were 48.0 ± 94.3ng/mL、65.7 ±109.0U/mL、27.4 ±18.1U/mL、54.8 ±43.8μg/L after chemotherapy respectively, the serum concentrations significantly decreased after 1 cycle of chemotherapy （P0.05）.Multiple regression analysis showed that serum CEA, CA199,CA125 concentration changes correlated with the effect of chemotherapy,while serum SF didn’t（t=1.822,P=0.074）. Conclusions：Serum CEA,CA199,CA125 concentration changes were associated with the efficacy of chemotherapy in colon cancer, which helps predict the effect of chemotherapy.