摘要
目的 :观察Omega-3多不饱和脂肪酸对不稳定型心绞痛患者血清炎症因子的影响及疗效。方法 :选择未行冠脉成形术(percutaneous coronary intervention,PCI)治疗的不稳定型心绞痛(unstable angina,UA)患者54例,随机分为Omega-3多不饱和脂肪酸组及安慰剂治疗组各27例。分别于入院时及治疗8周后检测患者空腹血清中白介素6、肿瘤坏死因子α、高敏C反应蛋白、IL-10及转化生长因子β等炎症因子表达变化;记录不良反应及半年内心血管事件发生率。结果:治疗后Omega-3组血清IL-6、TNF-α及CRP表达水平均较治疗前显著下降(P<0.05),IL-10、TGF-β表达显著上升(P<0.05)。对照组各炎症因子水平治疗前后变化差异无统计学意义(P>0.05);与对照组比较,Omega-3组用药8周后血清IL-6、TNF-α及CRP表达水平显著降低,IL-10、TGF-β表达显著上升;差异均有统计学意义(P<0.05)。治疗后半年内Omega-3组心血管终点事件发生率较对照组降低,但差异无统计学意义(P>0.05),两组不良反应发生比较差异无统计学意义。结论:不稳定型心绞痛患者口服Omega-3多不饱和脂肪酸能显著抑制炎症,纠正促炎和抑炎失衡,发挥其抗动脉粥样硬化作用。
Objective：To evaluate the changes and effects of Omega-3 polyunsaturated fatty acids（PUFAs） on serum levels of inflammatory factors in patients with unstable angina（UAP）. Methods：54 patients with UAP admitted between Mar 2013 and June 2014 were randomly divided into the Omega-3 PUFAs group（n=27） who received Omega-3 PUFAs, and the placebo group（n=27）. The serum levels of inflammatory factors such as tumor necrosis factor（TNF-α）, interleukin 6（IL-6）, High sensitivity C reactive protein（Hs-CRP）, IL-10 and transforming growth factorβ（TGF-β）were measured before and after treatment, and Major adverse cardiovascular event and side effects were observed. Results：after treatment, The serum expression levels of TNF-α, IL-6 and CRP in the Omega-3 PUFAs group were lower than the placebo group（P〈0.05）, and the serum expression levels of IL-10 and TGF-βwere higher than in the placebo group（P〈0.05）. The incidence rate of major adverse cardiovascular event in the Omega-3 PUFAs group was lower than in the conventional interventional group in half a year （P〈0.05） and side effects were similar between two groups. Conclusion：Taking Omega-3 PUFAs can depress the experssion of serum inflammatory factors in patients with UA, and treatment with Omega-3 PUFAs was safe and effective.
出处
《交通医学》
2015年第2期128-130,134,共4页
Medical Journal of Communications
