三阴性乳腺癌中p53的表达及临床病理因子间的相关性

The Expression of p53 in TNBC and the Correlation among the Clinicopathological Factors

目的探讨三阴性乳腺癌患者(TNBC)中p53的表达及与肿瘤大小(T分期)、淋巴结转移(N分期)、术后分期、年龄、月经状态间的关系。方法回顾性分析资料完整的40例TNBC与209例非三阴性乳腺癌(NTNBC)中p53的表达及TNBC中p53、T分期、N分期、术后分期、年龄、月经状态间的相关性。结果在TNBC中p53阳性表达率为65.0%,明显高于NTNBC的46.4%,差异显著,P值为0.038。在TNBC中,T分期与N分期、术后分期均呈正相关,相关系数分别为0.336、0.798,P值分别为0.034、0.000;N分期与月经状态呈负相关,相关系数为-0.368,P值为0.019;N分期与术后分期呈正相关,相关系数分别为0.730,P值为0.000;其余p53、T分期、N分期、术后分期、年龄、月经状态间无相关性。结论绝经前TNBC腋窝淋巴结转移风险增大。TNBC肿瘤越大,腋窝淋巴结转移越多,术后分期越晚,治疗效果不佳。TNBC中p53阳性表达增高,p53可以作为TNBC的治疗靶点。

Objective To explore the expression of p53 in triple-negative breast cancer （TNBC） and the correlation among the clinicopathologieal factors. Methods A retrospective study was made to the expressions of p53 in 40 cases with TNBC and 209 cases with non-triple-negative breast cancer （NTNBC）; the correlation among the expression of p53, TNM, age and menstruation status in TNBC cases was analyzed. Results The positive expression of p53 in cases with TNBC was 65.0%, much higher than that in cases with NTN- BC, which was 46.4%, the difference was obvious （P=0.038）; there existed a positive correlation between tumor size and axillary lymph node metastasis （r=0.336, P=0.034） and between tumor size and postoperative stage of TNM （r=0.798, P =0.000）; axillary lymph node metastasis was in negative correlation with menstruation status （r=-0.368, P=0.019） while it was in positive correlation with postopera- tive stage of TNM （r=0.730, P=0.000）; no correlation was observed among other factors. Conclusions The risk of TNBC axillary lymph mode metastasis is bigger before menopause; the bigger the size of TNBC t is, the heavier the axillary lymph node metastasis is; late postoperative stage of TNM leads to poor curative effect; the positive expression of p53 is high in TNBC, which may be taken as a target in the treatment of TNBC.