冠心病患者血清胆红素和超敏C反应蛋白水平与冠状动脉狭窄程度的相关性研究

Correlation between Serum Bilirubin and High-sensitivity C-reactive Protein Levels and Degree of Coronary Artery Stenosis in Patients with Coronary Heart Disease

目的探究冠心病患者血清胆红素、超敏C反应蛋白(hs-CRP)水平与冠状动脉狭窄程度的相关性。方法选取中山市石岐苏华赞医院2012年6月—2013年6月收治的65例冠心病患者为观察组,根据冠心病类型分为稳定型心绞痛组(SAP组,n=28)、不稳定型心绞痛组(UAP组,n=20)、急性心肌梗死组(AMI组,n=17);采用Gensini评分评价冠状动脉狭窄程度,其中1分8例、2分10例、4分28例、8分10例、16分9例;另选取同期在本院体检健康者50例为对照组。测定所有受试者血清胆红素〔总胆红素(TBi L)、直接胆红素(DBi L)、间接胆红素(IDBi L)〕及hs-CRP水平,分析其与冠心病患者冠状动脉狭窄程度的相关性。结果观察组患者血清TBi L、IDBi L、DBi L水平均低于对照组,血清hs-CRP水平高于对照组(P<0.05)。SAP组、UAP组患者血清TBi L、IDBi L、DBi L水平高于AMI组,血清hs-CRP水平低于AMI组(P<0.05)。随着冠心病患者Gensini评分增高,血清TBi L、IDBi L、DBi L水平不断降低,血清hs-CRP水平不断增高(P<0.05)。Pearson相关分析结果显示,冠心病患者Gensini评分与血清TBi L(r=-0.412,P=0.000)、IDBi L(r=-0.439,P=0.000)、DBi L(r=-0.387,P=0.002)水平呈负相关,与血清hs-CRP(r=0.378,P=0.000)水平呈正相关。结论血清TBi L、IDBi L、DBi L水平越低、hs-CRP水平越高提示冠心病患者冠状动脉狭窄越严重。

Objective To investigate the correlation between serum bilirubin and high-sensitivity C-reactive protein （ hs-CRP） levels and degree of coronary artery stenosis in patients with coronary heart disease. Methods From June 2012 to June 2013 in Shi Qi Su Hua -zan Hospital of Zhongshan,a total of 65 patients with coronary heart disease were selected as observation group,including 28 patients with stable angina pectoris（ SAP group）,20 patients with unstable angina pectoris （UAP group）,17 patients with acute myocardial infarction（AMI group）;a total of 50 healthy cases were selected as control group at the same time. According to Gensini score,the 65 patients with coronary heart disease were divided into subgroups A （Gensini score was 1,n=8）,B（Gensini score was 2,n=10）,C（Gensini score was 4,n=28）,D（Gensini score was 8,n=10）,E（Gensini score was 16,n=9）. Serum bilirubin（including TBiL,DBiL,IDBiL）and hs-CRP levels were detected,and their correlation with degree of coronary artery stenosis were analyzed. Results Serum TBiL, DBiL, IDBiL levels of observation group were statistically significantly higher than those of control group, while serum hs-CRP level of observation group was statistically significantly lower than that of control group（P﹤0. 05）. Serum TBiL,DBiL,IDBiL levels of groups SAP and UAP were statistically significantly higher than those of AMI group,while serum hs-CRP level of groups SAP and UAP was statistically significantly lower than that of control group,respectively（P﹤0. 05）. As Gensini score of patients with coronary heart disease increased,serum TBiL,DBiL,IDBiL levels decreased,serum hs-CRP level increased. Pearson correlation analysis showed that,Gensini score of patients with coronary heart disease was negatively correlated with serum level of TBiL（r= -0. 412,P=0. 000）,IDBiL（r= -0. 439,P=0. 000）,DBiL（r= -0. 387,P=0. 002）,respectively,was positively correlated with serum hs-CRP level（r =0. 378,P =0. 000）. Conclusion The lower of serum TBiL,DBiL, IDBiL levels and higher of serum hs-CRP level,the more severe of coronary artery stenosis in patients with coronary heart disease.