应用fMRI技术探查静息态经前期综合征肝气郁证患者中枢脑区定位

Application of fMRI Technology in Exploration of Central Brain Localization among Premenstrual Syndrome Patients with Liver-qi Depression in Resting-state

目的:探寻与经前期综合征肝气郁证发病密切相关的脑区。方法:采用BOLD-功能磁共振成像技术,影像学数据基于matlab平台的SPM 8软件以及rest软件进行图片处理,每个簇块体积阈值(Cluster)大于389个连续体素,单体素阈值P<0.05(校正后)的脑区定义为差异有统计学意义的区域,病例组和对照组采用双样本t检验。结果:PMS肝气郁证患者与正常对照相比,额叶、枕叶、岛叶、边缘叶、基底核、扣带回等脑区激活增强。结论:PMS肝气郁证患者发病与额叶、枕叶、岛叶、边缘叶、基底核、扣带回等脑区有关。

This study was aimed to explore brain regions which were closely related to the disease onset of premenstrual syndrome （PMS） with liver-qi depression. The BOLD-functional magnetic resonance imaging （fMRI） was used in the study. The processing of imaging data was based on the SPM 8 software and the REST software of the matlab platform. Each cluster was more than 389 continuous voxel. The brain region with single voxel of P 〈 0.05 （corrected） was defined as region with statistical significance. The 2 Sample T-Test was applied in the case group and the control group. The results showed that compared with the normal control group, the frontal lobe, occipital lobe, insula, limbic lobe, basal nuclei, and cingulate gyrus were activated in the PMS with liver-qi depression cases. It was concluded that the disease onset of PMS with frontal lobe, occipital lobe, insula, limbic lobe, basal liver-q/depression cases was related to brain regions such as nuclei, and cingulate gyrus.