41例老年2型糖尿病肾病合并高血压的疗效观察

Efficacy of Irbesartan Combined with Calcium Antagonist in the Treatment of 41 Elderly Patients with Type 2 Diabetic Nephropathy and Hypertension

目的探讨厄贝沙坦与钙离子拮抗剂联合疗法子在2型糖尿病肾病合并高血患者中的治疗效果。方法从该院2012年3月—.2014年3月收治的老年2型糖尿病肾病合并高血压患者82例为观察对象,随机分为观察组与对照组,每组41例,对照组行厄贝沙坦治疗,观察组在对照组基础上加用钙离子拮抗剂治疗,观察两组患者治疗效果。结果两组患者治疗前相关指标无明显差异,治疗后观察组指标均明显低于治疗前,且明显低于对照组,观察组治疗后不良事件发生率明显低于对照组,差异有统计学意义(P<0.05)。结论在2型糖尿病肾病合并高血压老年患者治疗中,采用厄贝沙坦与钙离子拮抗剂联合疗法,疗效切确,值得临床推广运用。

Objective To investigate the effect of irbesartan combined with calcium antagonist on patients with type 2 diabetic nephropathy and hypertension. Methods 82 elderly patients with type 2 diabetic nephropathy and hypertension admitted in our hospital from March 2012 to March 2014 were selected as the subjects and randomly divided into the observation group and the control group with 41 patients in each. The control group were treated by irbesartan, while the observation group were treated by irbesartan combined with calcium antagonist. And the therapeutic effect of both groups was observed. Results Before treatment, no significant differences in the relative indexes were found between the two groups. After treatment, the relative indexes in the observation group were obviously lower compared with those before treatment, and were much lower than those in the control group. The incidence of adverse events was significantly lower in the observation group than that in the control group after treatment, the difference was statistically significant（P〈0.05）. Conclusion For elderly patients with type 2 diabetic nephropathy and hypertension, the combination therapy of irbesartan and calcium antagonist has exact curative effect and is worthy of clinical application and promotion.