慢性乙型肝炎肝细胞HBsAg、HBcAg表达与肝组织病理学分析

The expression of the liver cell HBsAg,HBcAg in chronic hepatitis B and liver tissue pathology analysis

目的探讨慢性乙型病毒性肝炎肝细胞内HBsAg、HBcAg的表达与肝组织病理学的关系。方法对146例慢性乙型病毒性肝炎肝细胞内HBsAg、HBcAg的表达和肝组织病理学进行回顾性分析。结果 146例慢性乙型病毒性肝炎肝细胞内HBsAg、HBcAg的表达率分别为89.0%和80.8%,肝细胞HBc Ag胞桨阳性、胞桨+胞核阳性、胞核阳性的慢性乙型病毒性肝炎患者中,中度和重度炎症活动度的比例分别为75.0%、23.1%和8.3%;纤维化S0-S2、S3-S4的比例分别为50.0%、50.0%,73.1%、26.9%,86.1%、13.9%。结论慢性乙型病毒性肝炎肝细胞内HBsAg的表达是慢性HBV感染的一个标志,肝细胞内HBcAg的表达方式与肝组织炎症分级和纤维化分期相关,HBcAg胞桨阳性的慢性乙型病毒性肝炎患者组炎症活动度和纤维化程度,均显著高于HBcAg胞核阳性和胞核+胞桨阳性的慢性乙型病毒性肝炎患者组。

Objective To exploring the relationship of the liver cell HBsAg, HBcAg expression in chronic hepatitis B and liver tissue pathology analysis. Methods To retrospective analyze the liver cell HBsAg, HBcAg expression in 146 chronic hepatitis B patients and hepatic tissue pathrlogy. Results The frequency of liver cell HBsAg and HBcAg were 89, 0% 和 80.8% re- spectively. The proportion of moderate and severe inflammatory activity were 75.0%, 23.1%, 8.3% of positive HBcAg in cy- toplasm, nucleus, both cytoplasm and nucleus repectively, and fibrosis SO - $2, $3 - $4 were 50% and 50.0% , 73.1% and 26.9%, 86.1% and 13.9%. Conclusion The expression of HBsAg was marker for chronic HBV infection in liver cell; the expression of HBcAg has related to hepative tissue inflammation grading and stage of fibrosis. The inflammatory activity and fi- brosis have more severe in cytoplasm positive, compared with nucleus or both cytoplasm and nucleus.