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肠促胰岛素对糖尿病肾病的保护作用及机制 被引量:5

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摘要 2型糖尿病(T2DM)是影响人类健康的慢性非传染性疾病,我国最新调查显示,成人中T2DM患病率高达11.6%,约1.14亿人[1]。长期糖尿病及其导致的微血管及大血管并发症不仅严重影响健康,还给家庭及社会带来沉重的经济负担。糖尿病肾病是糖尿病主要的微血管并发症之一,约20%~30%的糖尿病患者发生糖尿病肾病。另外,糖尿病肾病还与心血管疾病的发病率及死亡率密切相关。然而,目前的防治措施不能完全阻止糖尿病肾病的进展,需研发新的药物。在过去近十年中,胰高血糖素样肽1(GLP-1)受体激动剂及二肽基肽酶Ⅳ(DPP-4)抑制剂已经用于治疗T2DM,这种基于肠促胰岛素的治疗在控制血糖之外对多脏器系统都有作用。本综述主要探讨肠促胰岛素对肾脏系统的保护作用及其可能机制。
出处 《中华糖尿病杂志》 CAS CSCD 2015年第5期331-333,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
基金 国家自然科学基金委员会面上项目(81370938) 上海市卫生和计划生育委员会优秀青年人才计划(XYQ2011002)
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