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EV71所致手足口病，完全征服的路还有多远？ 被引量：10

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摘要 手足口病是由20多种病毒引起的、在全球不同地区多次流行的常见传染病。近年在我国流行且引起重症及死亡的绝大多数为肠道病毒71型（enterovirus 71，EV71）C4亚型所致手足口病，主要临床特征为发热，手、足、口、臀部出现疱疹样皮疹，重症者可出现神经系统症状，少数病例可迅速发展为重症危重型，出现肺出血、心肺功能衰竭所致的顽固性休克及脑功能衰竭。
作者 喻文亮
机构地区 南京市儿童医院急诊科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2015年第6期587-591,共5页 Chinese Journal of Emergency Medicine
基金 江苏省临床医学科技专项（BL2014008） 江苏省中医药局项目（LZ13117）
关键词 手足口病 EV71 肠道病毒71型 征服 神经系统症状 心肺功能衰竭 常见传染病 脑功能衰竭
分类号 R725.1 [医药卫生—儿科]
  • 相关文献

参考文献24

  • 1Bible JM, Pantelidis P, Chan PK, et al. Genetic evolution of enterovirus 71: epidemiological and pathological implications [J]. Rev Med Virol, 2007, 17 (6) : 371-379.
  • 2Lin TY, Twu SJ, Ho MS, et al. Enterovirus 71 outbreaks, Taiwan : occurrence and recognition [J]. Emerg Infect Dis, 2003, 9 (3) : 291-293.
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二级参考文献10

  • 1} Prager P, Nolan M, Andrews IP, et al. Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors. Pediatr Crit Care Med, 2003,4(3 ) :377-381.
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共引文献19

同被引文献132

  • 1王德生,吕英,王晓丹,奚宁宁.脑血管病所致的迁延性昏迷、植物状态的康复研究[J].中国康复医学杂志,2004,19(9):704-705. 被引量：7
  • 2刘晓燕.小儿神经系统某些常见病的EEG表现[J].临床神经电生理学杂志,2007,16(2):112-115. 被引量：8
  • 3I-Iuang CC, Liu CC, Chang YC, et al. Neurologic complications in children with enterovirus 71 infection[ J]. N Engl J Med, 1999,341 ( 13 ) :936-942. DOI : 10. 1056/NEJM199909233411302.
  • 4Chen SC, Chang HL, Yan TR, et al. An eight-year study of epi- demiologic features of enterovirus 71 infection in Taiwan[ J]. Am J Trop Med Hyg, 2007,77(1) :188-191.
  • 5Sun LM, Zheng HY, Zheng HZ, et al. An enterovirus 71 epidem- ic in Guangdong Province of China, 2008 : epidemiological, clini- cal, and virogenic manifestations [ J ]. Jpn J Infect Dis, 2011,64 (1) :13-18.
  • 6Wang X, Peng W, Ren J, et al. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71 [J]. Nat Struct Mol Biol, 2012,19(4) :424-429. DOI: 10. 1038/nsmb. 2255.
  • 7Plevka P, Perera R, Cardosa J, et al. Crystal Structure of Human Enterovirus 71[J]. Science, 2012,336(6086) :1274. DOI: 10. 1126/science. 1218713.
  • 8Chen CS, Yao C, Lin SC, et al. Retrograde axonal transport: a major transmission route of enterovirus 71 in mice [ J l. J Virol, 2007,81 (17) :8996-9003. DOI : 10.1128/JVI. 00236-07.
  • 9Ong KC, Badmanathan M, Devi S, et al. Pathologic characteriza- tion of a murine model of human enterovirus 71 encephalomyelitis [J]. J Neuropathol Exp Neurol, 2008,67(6):532-542. DOI: 10. 1097/NEN. 0b013e31817713e7.
  • 10Wong KT, Munisamy B, Ong KC, et al. The distribution of in- flammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways [ J ]. J Neuro- pathol Exp Neurol, 2008,67 (2) :162-169. DOI: 10. 1097/uen. 0b013e318163a990.

引证文献10

二级引证文献60

中华急诊医学杂志
2015年 第6期

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