化浊解毒法治疗慢性萎缩性胃炎用药聚类分析

Cluster analysis of herbs used in treating chronic atrophic gastritis by resolving turbidity and removing toxin

目的:探讨运用聚类分析总结化浊解毒法治疗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的中医用药经验.方法:选择临床治疗CAG浊毒内蕴证的验方,借助SPSS18.0统计软件将涉及的中药先进行频数排序,而后将频次在30以上的中药做聚类分析,选用系统聚类中的欧氏距离平方法.结果:共有CAG浊毒内蕴证治验处方252条纳入研究,涉及186种药物,总用药6141频次.对53味出现频次在30以上的中药做聚类分析,结果得出了针对不同邪气的7个聚类方.结论:"浊毒"为湿、瘀、滞、积、毒、痈混杂交结而成,化浊解毒治疗CAG应构建祛湿、散瘀、通滞、化积、解毒、消痈"六位一体"的综合性治疗网络.

AIM： To discuss the experience in the treatment of chronic atrophic gastritis（CAG） using the Traditional Chinese Medicine＇s principle of resolving turbidity and removing toxin.METHODS： Effective prescriptions concerning the treatment of CAG with internal accumulation of turbid toxin as syndrome pattern were collected, and frequency sorting was exercised to the herbs, which would undergo hierarchical cluster analysis if their frequency was greater than 30, with the application of SPSS18.0software.RESULTS： A total of 252 prescriptions met the inclusive criteria, involving 186 herbs and6141 frequencies. Seven extracted prescriptions were explored according to the results of cluster analysis, which included 53 herbs with a frequency greater than 30.CONCLUSION： The formation of turbid toxin is mainly due to the mixture of dampness,stasis, stagnation, accumulation, heat-devil and carbuncles. The most precious experience when combating CAG should be the building of a comprehensive treatment network with the character of ＂six in one＂： Resolving dampness, dissipating blood stasis, soothing stagnation, dissolving accumulation, reducing heat-devil, and removing carbuncles.