抑癌基因PTEN、p27在胃癌组织中的表达及临床意义

Clinical significance of expression of PTEN and p27 in gastric carcinoma

目的:研究胃癌患者癌组织中抑癌基因PTEN、p27的表达,探讨其与胃癌侵袭、转移发生的关系.方法:SP免疫组织化学法对90例胃癌组织及癌旁正常对照胃组织中PTEN、P27表达进行观察.结果:胃癌组织PTEN蛋白表达的阳性率显著低于对照正常组织,其表达水平与胃癌分化程度、淋巴结转移有关.P27在胃癌中表达,其阳性表达率亦明显低于正常组织,P27的表达也与胃癌分化、淋巴结转移均有关.PTEN、P27之间阳性表达呈正相关.结论:PTEN、P27蛋白表达水平与胃癌组织的分化程度及淋巴结转移发生显著相关,胃癌组织分化程度越差,有淋巴结转移的PTEN、P27蛋白表达水平低.

AIM： To examine the expression PTEN and p27 proteins in gastric cancer and to analyze their relationship with the pathological stage,invasion and metastasis of this malignancy.METHODS： Immunohistochemical method was adopted to detect the expression of PTEN and P27 in 90 gastric cancer tissues and paired normal gastric tissues.RESULTS： The positive rate of PTEN proteinexpression in gastric cancer was significantly lower than that in the control normal group.PTEN protein expression was significantly associated with pathological differentiation and lymph node metastasis. The positive expression rate of P27 also considerably decreased in gastric cancer compared with the normal tissue.P27 expression was also significantly related with tumor differentiation and lymph node metastasis. There was a positive correlation between PTEN and P27 expression.CONCLUSION： PTEN and P27 protein expression is significantly correlated with tumor differentiation and lymph node metastasis in gastric carcinoma. PTEN and P27 are lowly expressed in poorly differentiated gastric carcinoma and gastric carcinoma with lymph node metastasis.