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阿德福韦酯致低血磷性骨软化症1例

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摘要 阿德福韦酯是一种较新的抗乙肝病毒药物,2002年9月在美国批准用于一线治疗慢性乙型肝炎,2005年4月在中国上市,阿德福韦酯是单磷酸腺苷核苷酸类似物,在细胞激酶的作用下被磷酸化为有活性的代谢产物即阿德福韦二磷酸盐,通过抑制HBV-DNA多聚酶的活性而起到抗乙肝病毒复制的作用。既往研究发现,慢性乙型肝炎口服阿德福韦酯30mg/d治疗48周,13%的患者可出现轻度肾功能损害[1],
出处 《中国中医骨伤科杂志》 CAS 2015年第6期69-70,共2页 Chinese Journal of Traditional Medical Traumatology & Orthopedics
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