C-反应蛋白和降钙素原对细菌感染的诊断价值比较

The Comparison of the Diagnostic Value of CRP and PCT in Bacterial Infection

目的:探讨C-反应蛋白(CRP)和降钙素原(PCT)对细菌感染的最佳临界值并比较两者的诊断性能。方法:测定66例细菌感染患者入院血清CRP、PCT水平以绘制受试者工作特征曲线(ROC曲线),根据曲线确定最佳临界值,根据曲线下面积(AUC)比较两者对细菌感染的诊断性能。结果:CRP最佳临界值11.9 mg/L(敏感性78.8%、特异性76.9%),PCT最佳临界值0.56 ng/m L(敏感性88.5%、特异性84.6%),PCT曲线下面积0.963,大于CRP曲线下面积的0.815。结论:PCT对细菌感染的诊断性能优于CRP。

Objective： To explore the optimal critical value of C- reactive protein（ CRP） and procalcitonin（ PCT） in diagnosis of bacterial infection. Methods： Measured the serum CRP and PCT level of 66 patients when they entered the hospital and created the receiver operating characteristic curve（ ROC） and identified the optimal cut- off value accordingly. Compared with the diagnostic value of CRP and PCT depend on the ROC curve（ AUC）. Results： The optimal critical value of CRP was11. 9 mg / L（ sensitivity 78. 8%,specificity 76. 9%）,the optimal critical value of PCT was 0. 56 ng / m L（ sensitivity 88. 5%,specificity 84. 6%）,The AUC of PCT was 0. 963 while AUC of CRP was 0. 815. Conclusion： The diagnostic value of PCT is better than that of CRP in bacterial infection.