2型糖尿病并发心血管疾病危险因素Logistic 回归分析

Logistic regression analysis of risk factors of Type 2 diabetes mellitus complicated with cardiovascular disease factors

目的：探讨2型糖尿病（T2DM）并发心血管疾病（CVD）的主要危险因素。方法选择 T2DM合并 CVD 患者128例为 CVD 组，单纯 T2DM患者107例为对照组，采用 Logistic 回归方法对其并发 CVD 的危险因素进行分析。结果有 T2DM家族史、素食膳食或高血压患者并发 CVD 的危险为其他患者的1．535倍（OR ＝1．535，95％CI ＝1．145，2．057，P ＝0．036）、41．3％（OR ＝0．413，95％CI ＝0．210，0．815，P ＝0．024）和2.077倍（OR ＝2．077，95％ CI ＝1．301，2．813，P ＝0．010）。T2DM 患者 TG、PBG、LDL-C、HDL-C 每升高1 mmol／L，其并发 CVD 的危险为其他患者的1．192倍（OR ＝1．192，95％ CI ＝1．012，1．372，P ＝0．023）、1．125倍（OR ＝1．125，95％CI ＝1．043，1．218，P ＝0．028）、1．712倍（OR ＝1．712，95％CI ＝1．203，2．231，P ＝0.009）和42．6％（OR ＝0.426，95％CI ＝0．239，0．776，P ＝0．011）；HbA1c 每升高1％，其并发 CVD 的危险为其他患者的1．284倍（OR ＝1．284，95％CI ＝1．132，1．413，P ＝0．013）；BMI 每增加1 kg／m2，其并发 CVD 的危险为其他患者的1．508倍（OR ＝1．508，95％CI ＝1．143，1．825，P ＝0．026）；C2每增加1 mL／mmHg ＆#215;100，其并发CVD 的危险为其他患者的33．9％（OR ＝0．539，95％CI ＝0．384，0．826，P ＝0．007）。结论T2DM家族史、高血压、TG、PBG、LDL-C、HbA1c 和 BMI 是 T2DM并发 CVD 的主要危险因素，而素食膳食、HDL-C 和 C2是保护因素。

Objective To explore the main risk factors of type 2 diabetes mellitus（T2DM）complicated with cardiovascular disease（CVD）.Methods The T2DMof 128 cases of CVD associated with CVD group were selected, the patients with T2DM 107 cases were selected as control group,used Logistic regression method for the analysis of the risk factors of concurrent CVD.Results The risk of CVD in patients with a family history of T2DM was 1.535 times of that of the other patients （OR =1.535,95%CI =1.145,2.057,P =0.036）,the vegetarian diet patients was 41.3% （OR =0.413,95%CI =0.210,0.815,P =0.024）,in patients with hypertension was 2.077 times （OR =2.077,95%CI =1.301,2.813,P =0.010）.T2DM patients with TG,PBG,LDL -C,HDL -C per 1mmol/L rise,the risk of concurrent CVD was 1.192 times of that of the other patients （OR =1.192,95%CI 1.012,1.372, P =0.023）,1.125 times（OR =1.125,95%CI =1.043,1.218,P =0.028）,1.712 times （OR =1.712,95%CI =1.203,2.231,P =0.009）and 42.6% （OR =0.426,95%CI =0.239,0.776,P =0.011）;HbA1c increased every 1%,the risk of concurrent CVD was 1.284 times of that of theother patients （OR =1.284,95%CI =1.132,1.413, P =0.013）;BMI increased by 1kg/m2 ,the risk of concurrent CVD was 1.508 times of that of the other patients （OR =1.508,95%CI =1.143,1.825,P =0.026）;C2 increased by 1mL/mmHg ×100,the risk was the other patient＇s 33.9% （OR =1.508,95%CI =1.143,1.825,P =0.026）.Conclusion Family history of T2DM,hypertension, TG,PBG,LDL -C,HbA1c and BMI are major risk factors for T2DMwith CVD;vegetarian diet,HDL -C and C2 are protective factors.