老年2型糖尿病大血管病变患者血清超敏C反应蛋白及白细胞介素17检测的临床意义

The clinical significance of the detection of serum hs -CRP and interleukin -17 in senium type 2 diabetes with macroangiopathy

目的：探讨血清超敏 C 反应蛋白（hs-CRP）和白细胞介素17（IL-17）与老年人2型糖尿病（T2DM）大血管并发症的关系及临床意义。方法采用 ELISA 和免疫比浊法分别检测80例老年 T2DM大血管并发症患者、80例老年无大血管并发症的 T2DM患者血清 IL-17和 hs-CRP 浓度，并以80例健康老年人作为对照组。结果老年 T2DM大血管并发症患者血清 IL-17和 hs-CRP 浓度明显高于老年无大血管并发症患者和对照组（t ＝19．18，23．14，均 P ＜0．05），老年无大血管并发症患者血清 IL-17和 hs-CRP 浓度高于对照组（t ＝23．64，19．97，均 P ＜0．05）；老年 T2DM大血管并发症患者不同亚组间的血清 hs-CRP 和 IL-17浓度差异均无统计学意义（F ＝1．08，1．49，均 P ＞0．05）；相关分析显示，血清 hs-CRP 和 IL-17水平呈正相关（r ＝0.712， P ＜0．01）。结论hs-CRP 和 IL-17可能参与糖尿病大血管病变的炎性反应过程，其血清水平升高可能与老年人 T2DM大血管并发症发生发展有关，检测其水平可能有助于老年人糖尿病大血管并发症的早期诊治，作为病情变化的监测指标。

Objective To explore the relationship between serum hs -CRP,IL -17 levels and senium type 2 diabetic macrovascular complications and its clinical significance.Methods The serum levels of hs -CRP and IL-17 were measured with immunoturbidimetry and ELISA respectively in 80 cases of type 2 diabetic patients with macrovascular complications,80 cases of the absence of any major vascular complications in patients with type 2 diabetes and 80 healthy subjects as the control.Results The serum hs -CRP and IL -17 levels of senium type 2 diabetic Patients with macrovascular complications were significantly higher than those of patients without macrovascular complication and healthy control group（t =19.18,23.14,all P 〈0.01）;And serum hs -CRP and IL -17 levels of seniumtype 2 diabetic patients without macrovascular complications were also significantly higher than those of the healthy control group （t =23.64,19.97,all P 〈0.05 ）;While serum hs -CRP and IL -17 levels in different subgroup of type 2 diabetic patients with macrovascular complications were no significantly statistical significance（F =1.08,1.49,all P 〉0.05）;In patients of type 2 diabetic Patients with macrovascular complications,hs -CRP was positively correlated with serum IL -17（r =0.712,P 〈0.05）.Conclusion Hs -CRP and IL -17might be involved in the process of inflammatory response to diabetic macroangiopathy,and may have important role in the pathogenesis of senium type 2 diabetic patients with macrovascular complications.Detemination of hs -CRP and IL -17 levels in type 2 diabetic patients may be useful for early detecting diabetic macrovascular complications and serve as the index in monitoring the state of diabetic macrovascular complications.