摘要
目的:探讨血清超敏 C 反应蛋白(hs-CRP)和白细胞介素17(IL-17)与老年人2型糖尿病(T2DM)大血管并发症的关系及临床意义。方法采用 ELISA 和免疫比浊法分别检测80例老年 T2DM大血管并发症患者、80例老年无大血管并发症的 T2DM患者血清 IL-17和 hs-CRP 浓度,并以80例健康老年人作为对照组。结果老年 T2DM大血管并发症患者血清 IL-17和 hs-CRP 浓度明显高于老年无大血管并发症患者和对照组(t =19.18,23.14,均 P <0.05),老年无大血管并发症患者血清 IL-17和 hs-CRP 浓度高于对照组(t =23.64,19.97,均 P <0.05);老年 T2DM大血管并发症患者不同亚组间的血清 hs-CRP 和 IL-17浓度差异均无统计学意义(F =1.08,1.49,均 P >0.05);相关分析显示,血清 hs-CRP 和 IL-17水平呈正相关(r =0.712, P <0.01)。结论hs-CRP 和 IL-17可能参与糖尿病大血管病变的炎性反应过程,其血清水平升高可能与老年人 T2DM大血管并发症发生发展有关,检测其水平可能有助于老年人糖尿病大血管并发症的早期诊治,作为病情变化的监测指标。
Objective To explore the relationship between serum hs -CRP,IL -17 levels and senium type 2 diabetic macrovascular complications and its clinical significance.Methods The serum levels of hs -CRP and IL-17 were measured with immunoturbidimetry and ELISA respectively in 80 cases of type 2 diabetic patients with macrovascular complications,80 cases of the absence of any major vascular complications in patients with type 2 diabetes and 80 healthy subjects as the control.Results The serum hs -CRP and IL -17 levels of senium type 2 diabetic Patients with macrovascular complications were significantly higher than those of patients without macrovascular complication and healthy control group(t =19.18,23.14,all P 〈0.01);And serum hs -CRP and IL -17 levels of seniumtype 2 diabetic patients without macrovascular complications were also significantly higher than those of the healthy control group (t =23.64,19.97,all P 〈0.05 );While serum hs -CRP and IL -17 levels in different subgroup of type 2 diabetic patients with macrovascular complications were no significantly statistical significance(F =1.08,1.49,all P 〉0.05);In patients of type 2 diabetic Patients with macrovascular complications,hs -CRP was positively correlated with serum IL -17(r =0.712,P 〈0.05).Conclusion Hs -CRP and IL -17might be involved in the process of inflammatory response to diabetic macroangiopathy,and may have important role in the pathogenesis of senium type 2 diabetic patients with macrovascular complications.Detemination of hs -CRP and IL -17 levels in type 2 diabetic patients may be useful for early detecting diabetic macrovascular complications and serve as the index in monitoring the state of diabetic macrovascular complications.
出处
《中国基层医药》
CAS
2015年第11期1606-1608,共3页
Chinese Journal of Primary Medicine and Pharmacy