EOF方案化疗联合体外高频热疗治疗晚期原发性肝癌的临床观察

The clinical observation of advanced primary liver cancer under the chemotherapy of hyperthermia combined with EOF approach

目的探讨EOF方案化疗联合体外高频热疗治疗晚期原发性肝癌的临床疗效。方法选择晚期原发性肝癌患者75例，按区组随机化分组法随机分为两组，单纯化疗组（对照组）37例，采用EOF方案治疗；化疗联合热疗组（治疗组）38例，采用EOF方案化疗联合体外高频热疗治疗。比较两组临床疗效。结果治疗组有效率、疾病控制率、1年生存率、2年生存率分别为73．68％、92．1％、57．8％、10．5％，对照组有效率、疾病控制率、1年生存率、2年生存率分别为48．6％、56．8％、45．9％、5．4％，两组差异均有统计学意义（χ^2=15．53、15．42、16．40、15．72，均P〈0．05）。结论EOF方案化疗联合体外高频热疗治疗晚期原发性肝癌，可明显提高临床疗效和生存时间，不增加化疗的毒副反应。

Objective To discuss the clinical efficacy of advanced primary liver cancer under the chemother- apy of hyperthermia combined with EOF approach. Methods 75 patient samples who had advanced primary liver cancer in total were chosen and were divided into the two groups randomly. The control group containing 37 patient samples had advanced primary liver cancer which would be applied with EOF approach. The treatment group contai- ning 38 samples had advanced primary liver cancer. The treatment strategy was to apply EOF approach combined with high - frequency hyperthermia in vitro. Results The total rate of efficiency on the treatment group and control group was 73.68% vs 48.6%. The DCR rate was 92.1% versus 56.8% , 1 year survival rate was 57.8% versus 45.9% and 2 years survival rate was 10.5% versus 5.4% which showed that the results of the treatment group was obviously better than that of the control group. Conclusion The method that combining the chemotherapy of hyperthermia with EOF to treat advanced primary liver cancer can obviously improve clinical efficacy and survival period. What＇s better is that this approach will not increase the toxicity of chemotherapy.