龙血竭联合獾油治疗放射性皮肤损伤的疗效观察

Efficacy of Long xue jie capsule combined with Badger Oil treatment of radiotherapy -induced injuries of skin

目的：观察龙血竭联合獾油治疗头颈部肿瘤放疗引起放射性皮肤损伤的临床疗效。方法选取接受放射治疗中出现Ⅱ～Ⅳ级急性放射性皮肤损伤患者128例，采用信封法随机分为研究组和对照组，研究组从出现放射性皮炎开始用獾油外涂于照射区皮肤，再用龙血竭粉末外涂皮损区，每天涂1～2次，7 d 为1个疗程，直到创面愈合。对照组从出现放射性皮炎用0．9％氯化钠注射液、地塞米松、庆大霉素将纱布湿后湿敷创面30 min，每天1～2次，7 d 为1个疗程。比较两组放射性湿性皮炎的治疗效果及放疗中断时间、皮损愈合时间。结果研究组治愈率96．9％，有效率为100．0％，无效率为0％；对照组治疗率为50．0％，有效率80．0％，无效率为20％；两组差异均有统计学意义（χ2＝14．64、11．86、11．48，均 P ＜0．01）。研究组皮肤损伤绝大多数在1周内愈合，无患者终止放疗；对照组13例终止放疗；研究组中断时间为（3．8±1．4）d，对照组中断时间为（8．8±1．6）d；研究组皮损愈合时间（5．6±0．6）d，对照组皮损愈合时间（10．6±0．8）d；两组差异均有统计学意义（χ2＝6．68、6．95、11．48，均 P ＜0．05）。结论龙血竭联合獾油治疗放射性皮肤损伤疗效显著，不仅能缩短愈合时间，且使用方便、经济、安全，具有一定的临床使用价值。

Objective To evaluate the effects of Long xuejie capsule combined with Badger Oil on head and neck cancer radiotherapy -induced radiation injuries of skin application value.Methods The received radiation therapy in Ⅱ -Ⅳacute radioactive skin injury in 128 cases were selected.Used the envelope method,they were ran-domly divided into the research group and the control group.Outside the team starts from a radioactive dermatitis with badger oil apply skin irradiation area,with a dragon dragon＆#39;s blood powder coating outside skin area.Apply 1 -2 times a day,seven days for a course of treatment until wound healing.The control group from a radioactive dermatitis with 0.9% sodium chloride injection,dexamethasone,gentamycin gauze wet moist wound after 30min,1 -2 times a day, 7 days for a course of treatment.Compare the therapeutic effect of the two groups of wet radioactive dermatitis and interruption of radiotherapy and skin lesion healing time.Results The effective rate of the study group was 90.6%, the cure rate was 100%.The effective rate of the control group was 80%,the treatment rate was 62.5%.There was a significant difference between the two groups （χ2 =14.64,11.86,11.48.P 〈0.01）.The vast majority of the study group in a week skin lesions healed,no patients discontinued radiotherapy,the control group 13 cases of termination of radiotherapy,interruption time study group （3.8 ±1.4）d,group interrupt time （8.8 ±1.6）d,lesion healing time of the study group （5.6 ±0.6）d,lesion healing time in the control group （10.6 ±0.8）d.There was a significant differ-ence between the two groups （χ2 =6.68,6.95,11.48,all P 〈0.05,significant difference）.Conclusion Longxuejie capsule combined Badger Oil has significant efficacy in the treatment of radioactive skin injury.It could shorten the healing time,and the method is convenient,economic,security and has certain clinical value.